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Anti-NR3C2/Mineralocorticoid receptor Polyclonal Antibody 2
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Catalog No. TMAB-09621
Anti-NR3C2/Mineralocorticoid receptor Polyclonal Antibody 2 is a Rabbit antibody targeting NR3C2/Mineralocorticoid receptor. Anti-NR3C2/Mineralocorticoid receptor Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF,FCM.
Anti-NR3C2/Mineralocorticoid receptor Polyclonal Antibody 2
Anti-NR3C2/Mineralocorticoid receptor Polyclonal Antibody 2
😃Good
Catalog No. TMAB-09621
Anti-NR3C2/Mineralocorticoid receptor Polyclonal Antibody 2 is a Rabbit antibody targeting NR3C2/Mineralocorticoid receptor. Anti-NR3C2/Mineralocorticoid receptor Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF,FCM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-NR3C2/Mineralocorticoid receptor Polyclonal Antibody 2 is a Rabbit antibody targeting NR3C2/Mineralocorticoid receptor. Anti-NR3C2/Mineralocorticoid receptor Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF,FCM. |
| Ig Type | IgG |
| Reactivity | Human,Mouse (predicted:Rat,Chicken,Dog,Pig,Cow,Rabbit) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 1μg/Test |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Cytoplasmic and nuclear in the absence of ligand; nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane. |
| Tissue Specificity | Ubiquitous. Highly expressed in distal tubules, convoluted tubules and cortical collecting duct in kidney, and in sweat glands. Detected at lower levels in cardiomyocytes, in epidermis and in colon enterocytes. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Steroid receptors are ligand dependent, intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. Mineralocorticoids are a family of steroids, secreted by the adrenal cortex, necessary for the regulation of a number of metabolic processes including electrolyte regulation. These compounds exert their effect through their interaction with the mineralocorticoid receptor and that complex's subsequent association with DNA. Given the function of mineralocorticoids, it is not surprising to find that the kidney is a primary target organ for mineralocorticoids and that this organ has been shown to contain Mineralocorticoid Receptor. |
| Immunogen | KLH conjugated synthetic peptide: human Mineralocorticoid receptor |
| Antigen Species | Human |
| Gene Name | NR3C2 |
| Gene ID | |
| Protein Name | Mineralocorticoid receptor |
| Uniprot ID | |
| Function | Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels. |
| Molecular Weight | Theoretical: 107 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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