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SCH 42495

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Catalog No. T12641LCas No. 136511-43-8

SCH 42495 is an orally active neutral metalloendopeptidase inhibitor and serves as the ethyl ester prodrug of SCH 42354.

SCH 42495
Other Forms of SCH 42495:

SCH 42495

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Catalog No. T12641LCas No. 136511-43-8
SCH 42495 is an orally active neutral metalloendopeptidase inhibitor and serves as the ethyl ester prodrug of SCH 42354.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$1,5206-8 weeks6-8 weeks
50 mg$1,9806-8 weeks6-8 weeks
100 mg$2,5006-8 weeks6-8 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
SCH 42495 is an orally active neutral metalloendopeptidase inhibitor and serves as the ethyl ester prodrug of SCH 42354.
In vitro
SCH 42354 inhibits the hydrolysis of leu-enkephalin and ANF (IC50: 8.3 and 10.0 nM, respectively) [1].
In vivo
SCH 42495 (oral doses of 1, 3, or 10 mg/kg) produces significant reductions in blood pressure in DOCA-N a hypertensive rats of 22±6, 43±7, and 62±12 mm Hg, respectively. SCH 42495 (30 mg/kg; oral gavage; twice daily) leads to a significant reduction in pulmonary vascular remodeling and ventricular hypertrophy in hypoxic rats after 10 days. Treatment with SCH 42495 (30 mg/kg; oral gavage; twice daily) resulting in a decrease in cardiovascular remodeling secondary to chronic hypoxia in rats [1][2].
Chemical Properties
Molecular Weight411.58
FormulaC20H29NO4S2
Cas No.136511-43-8
Smiles[C@H](CC1=C(C)C=CC=C1)(C(N[C@H](C(OCC)=O)CCSC)=O)CSC(C)=O
Relative Density.1.158 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SCH-42495SCH42495SCH 42495NEP
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