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PRDX1-IN-1

Name: PRDX1-IN-1
Brand: TargetMol
SKU: T78785
Price: 599 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T78785Cas No. 2996096-63-8

PRDX1-IN-1 is a selective and potent PRDX1 inhibitor with potential anti-inflammatory and anticancer activity for the study of breast and esophageal cancer.

PRDX1-IN-1

🥰Excellent

Purity: 98.04%

Catalog No. T78785Cas No. 2996096-63-8

PRDX1-IN-1 is a selective and potent PRDX1 inhibitor with potential anti-inflammatory and anticancer activity for the study of breast and esophageal cancer.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$599	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.04%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	PRDX1-IN-1 is a selective and potent PRDX1 inhibitor with potential anti-inflammatory and anticancer activity for the study of breast and esophageal cancer.
In vitro	PRDX1-IN-1 (0.5-10 μM; 48 hours) was able to inhibit the proliferative activity of lung cancer cell lines (LTEP-a-2 and H1975), and human breast cancer cell line (MDA-MB-231)[1].
In vivo	PRDX1-IN-1 (0.5 or 1 mg/kg; once daily for 19 days; intraperitoneal injection) treatment in C57BL/6J male mice inoculated with Lewis cells (lung cancer) was found to significantly inhibit tumor growth and induce morphological changes in tumor cells, including cell aggregation, contraction, and nuclear chromatin margination[1].

Chemical Properties

Molecular Weight	713.95
Formula	C₄₆H₅₅N₃O₄
Cas No.	2996096-63-8
Smiles	O=C(OC1=C(C)C2=CC=C([C@](CC[C@]3(C)[C@@]4([H])C[C@@](C(NCC5=C(C)N=C(C)C(C)=N5)=O)(C)CC3)(C)[C@@]4(C)CC6)[C@]6(C)C2=CC1=O)/C=C/C7=CC=CC=C7
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (112.05 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (4.62 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4007 mL	7.0033 mL	14.0066 mL	70.0329 mL
5 mM	0.2801 mL	1.4007 mL	2.8013 mL	14.0066 mL
10 mM	0.1401 mL	0.7003 mL	1.4007 mL	7.0033 mL
20 mM	0.0700 mL	0.3502 mL	0.7003 mL	3.5016 mL
50 mM	0.0280 mL	0.1401 mL	0.2801 mL	1.4007 mL
100 mM	0.0140 mL	0.0700 mL	0.1401 mL	0.7003 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc