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PRDX1-IN-1

Name: PRDX1-IN-1
Brand: TargetMol
SKU: T78785
Price: 599 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T78785Cas No. 2996096-63-8

PRDX1-IN-1 is a selective and potent PRDX1 inhibitor with potential anti-inflammatory and anticancer activity for the study of breast and esophageal cancer.

PRDX1-IN-1

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Purity: 98.04%

Catalog No. T78785Cas No. 2996096-63-8

PRDX1-IN-1 is a selective and potent PRDX1 inhibitor with potential anti-inflammatory and anticancer activity for the study of breast and esophageal cancer.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$599	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.04%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	PRDX1-IN-1 is a selective and potent PRDX1 inhibitor with potential anti-inflammatory and anticancer activity for the study of breast and esophageal cancer.
In vitro	PRDX1-IN-1 (0.5-10 μM; 48 hours) was able to inhibit the proliferative activity of lung cancer cell lines (LTEP-a-2 and H1975), and human breast cancer cell line (MDA-MB-231)[1].
In vivo	PRDX1-IN-1 (0.5 or 1 mg/kg; once daily for 19 days; intraperitoneal injection) treatment in C57BL/6J male mice inoculated with Lewis cells (lung cancer) was found to significantly inhibit tumor growth and induce morphological changes in tumor cells, including cell aggregation, contraction, and nuclear chromatin margination[1].

Chemical Properties

Molecular Weight	713.95
Formula	C₄₆H₅₅N₃O₄
Cas No.	2996096-63-8
Smiles	O=C(OC1=C(C)C2=CC=C([C@](CC[C@]3(C)[C@@]4([H])C[C@@](C(NCC5=C(C)N=C(C)C(C)=N5)=O)(C)CC3)(C)[C@@]4(C)CC6)[C@]6(C)C2=CC1=O)/C=C/C7=CC=CC=C7

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (112.05 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (4.62 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4007 mL	7.0033 mL	14.0066 mL	70.0329 mL
5 mM	0.2801 mL	1.4007 mL	2.8013 mL	14.0066 mL
10 mM	0.1401 mL	0.7003 mL	1.4007 mL	7.0033 mL
20 mM	0.0700 mL	0.3502 mL	0.7003 mL	3.5016 mL
50 mM	0.0280 mL	0.1401 mL	0.2801 mL	1.4007 mL
100 mM	0.0140 mL	0.0700 mL	0.1401 mL	0.7003 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc