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Thiomyristoyl

Name: Thiomyristoyl
Brand: TargetMol
SKU: T3447
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3447Cas No. 1429749-41-6

Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.

Thiomyristoyl

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Purity: 99.16%

Catalog No. T3447Cas No. 1429749-41-6

Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.

Pack Size	Price	Availability
1 mg	$52	In Stock
2 mg	$70	In Stock
5 mg	$88	In Stock
10 mg	$126	In Stock
25 mg	$239	In Stock
50 mg	$401	In Stock
100 mg	$597	In Stock
1 mL x 10 mM (in DMSO)	$126	In Stock

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Purity:99.16%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.
Targets&IC50	SIRT2:28 nM, SIRT1:98 μM
In vitro	In a breast cancer mouse model, Thiomyristoyl inhibits SIRT2 and tumor growth, while also reducing the levels of the c-Myc protein. The anticancer effects of Thiomyristoyl are positively correlated with the reduction of c-Myc levels.
In vivo	Thiomyristoyl exhibits weak inhibition towards SIRT3/5/6/7. It can reduce the level of c-MYC in cancer cells in vitro, with the extent of c-MYC reduction directly proportional to the cell line’s sensitivity to Thiomyristoyl.
Cell Research	Human MCF-7 cells are grown in DMEM media contained 10% (vol/vol) heat-inactivated fetal bovine serum and 1% penicillin-streptomycin and treated with in the presence of 200 nM TSA for 6 hr. The acetylation level of p53 protein is determined by western blot using anti-acetyl-p53 (K382) antibody. β-actin serves as a loading control. (Only for Reference)

Chemical Properties

Molecular Weight	581.85
Formula	C₃₄H₅₁N₃O₃S
Cas No.	1429749-41-6
Smiles	CCCCCCCCCCCCCC(=S)NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1ccccc1
Relative Density.	1.077 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (171.87 mM), Sonication is recommended.

Chloroform: Soluble

H2O: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7187 mL	8.5933 mL	17.1866 mL	85.9328 mL
5 mM	0.3437 mL	1.7187 mL	3.4373 mL	17.1866 mL
10 mM	0.1719 mL	0.8593 mL	1.7187 mL	8.5933 mL
20 mM	0.0859 mL	0.4297 mL	0.8593 mL	4.2966 mL
50 mM	0.0344 mL	0.1719 mL	0.3437 mL	1.7187 mL
100 mM	0.0172 mL	0.0859 mL	0.1719 mL	0.8593 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc