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ZM39923 hydrochloride

Name: ZM39923 hydrochloride
Brand: TargetMol
SKU: T6145
Price: 54 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6145Cas No. 1021868-92-7

Alias ZM 39923 HCl, JAK3 Inhibitor IV

ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase.

ZM39923 hydrochloride

🥰Excellent

Purity: 99.48%

Catalog No. T6145Alias ZM 39923 HCl, JAK3 Inhibitor IVCas No. 1021868-92-7

ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$54	In Stock	In Stock
10 mg	$96	In Stock	In Stock
25 mg	$179	In Stock	In Stock
50 mg	$327	In Stock	In Stock
100 mg	$487	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$97	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.48%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase.
Targets&IC50	JAK3:7.1 (pIC50), TGase 2:10 nM, EGFR:5.6 (pIC50), JAK1:4.4 (pIC50), CDK4:5.0 (pIC50), Lck:5.0 (pIC50)
Synonyms	ZM 39923 HCl, JAK3 Inhibitor IV

Chemical Properties

Molecular Weight	367.91
Formula	C₂₃H₂₅NO·HCl
Cas No.	1021868-92-7
Smiles	Cl.CC(C)N(CCC(=O)C1=CC=C2C=CC=CC2=C1)CC1=CC=CC=C1
Relative Density.	no data available

Storage & Solubility Information

Storage

store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 8 mg/mL (21.74 mM), Sonication is recommended.

DMSO: 28 mg/mL (76.11 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.44 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7181 mL	13.5903 mL	27.1806 mL	135.9028 mL
5 mM	0.5436 mL	2.7181 mL	5.4361 mL	27.1806 mL
10 mM	0.2718 mL	1.3590 mL	2.7181 mL	13.5903 mL
20 mM	0.1359 mL	0.6795 mL	1.3590 mL	6.7951 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0544 mL	0.2718 mL	0.5436 mL	2.7181 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc