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ZM39923 hydrochloride

Name: ZM39923 hydrochloride
Brand: TargetMol
SKU: T6145
Price: 54 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6145Cas No. 1021868-92-7

Alias ZM 39923 HCl, JAK3 Inhibitor IV

ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase.

ZM39923 hydrochloride

🥰Excellent

Purity: 98.05%

Catalog No. T6145Alias ZM 39923 HCl, JAK3 Inhibitor IVCas No. 1021868-92-7

ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase.

Pack Size	Price	Availability
5 mg	$54	In Stock
10 mg	$96	In Stock
25 mg	$179	In Stock
50 mg	$327	In Stock
100 mg	$488	In Stock
1 mL x 10 mM (in DMSO)	$97	In Stock

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Purity:98.05%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase.
Targets&IC50	CDK4:5.0 (pIC50), Lck:5.0 (pIC50), EGFR:5.6 (pIC50), JAK3:7.1 (pIC50), JAK1:4.4 (pIC50), TGase 2:10 nM
Synonyms	ZM 39923 HCl, JAK3 Inhibitor IV

Chemical Properties

Molecular Weight	367.91
Formula	C₂₃H₂₅NO·HCl
Cas No.	1021868-92-7
Smiles	Cl.CC(C)N(CCC(=O)C1=CC=C2C=CC=CC2=C1)CC1=CC=CC=C1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 8 mg/mL (21.74 mM), Sonication is recommended.

DMSO: 28 mg/mL (76.11 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.44 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7181 mL	13.5903 mL	27.1806 mL	135.9028 mL
5 mM	0.5436 mL	2.7181 mL	5.4361 mL	27.1806 mL
10 mM	0.2718 mL	1.3590 mL	2.7181 mL	13.5903 mL
20 mM	0.1359 mL	0.6795 mL	1.3590 mL	6.7951 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0544 mL	0.2718 mL	0.5436 mL	2.7181 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc