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ML-178

Name: ML-178
Brand: TargetMol
SKU: T22102
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T22102Cas No. 1355026-47-9

Alias CYM50179

ML-178, a dichlorobenzene, is a potent and selective agonist of sphingosine-1-phosphate receptor 4 (S1PR4), with an EC50 of 46 nM, and has no effect on other S1P receptors at a concentration of 25 μM.

ML-178

🥰Excellent

Purity: 95.92%

Catalog No. T22102Alias CYM50179Cas No. 1355026-47-9

Pack Size	Price	Availability
2 mg	$42	In Stock
5 mg	$67	In Stock
10 mg	$117	In Stock
25 mg	$247	In Stock
50 mg	$422	In Stock
100 mg	$628	In Stock
1 mL x 10 mM (in DMSO)	$75	In Stock

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Batch Information

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Purity:95.92%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	ML-178, a dichlorobenzene, is a potent and selective agonist of sphingosine-1-phosphate receptor 4 (S1PR4), with an EC50 of 46 nM, and has no effect on other S1P receptors at a concentration of 25 μM.
Targets&IC50	S1P4 receptor:46 nM (EC50)
Synonyms	CYM50179

Chemical Properties

Molecular Weight	441.93
Formula	C₁₃H₉Br₂Cl₂NO₂
Cas No.	1355026-47-9
Smiles	Clc1ccc(OCCOc2ccc(Br)nc2Br)c(Cl)c1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 15 mg/mL (33.94 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2628 mL	11.3140 mL	22.6280 mL	113.1401 mL
5 mM	0.4526 mL	2.2628 mL	4.5256 mL	22.6280 mL
10 mM	0.2263 mL	1.1314 mL	2.2628 mL	11.3140 mL
20 mM	0.1131 mL	0.5657 mL	1.1314 mL	5.6570 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc