Shopping Cart
Remove All
Your shopping cart is currently empty
ML-178
Copy Product Info
🥰Excellent
Catalog No. T22102Cas No. 1355026-47-9
Alias CYM50179
ML-178, a dichlorobenzene, is a potent and selective agonist of sphingosine-1-phosphate receptor 4 (S1PR4), with an EC50 of 46 nM, and has no effect on other S1P receptors at a concentration of 25 μM.
ML-178
Copy Product Info🥰Excellent
Purity: 95.92%
Catalog No. T22102Alias CYM50179Cas No. 1355026-47-9
ML-178, a dichlorobenzene, is a potent and selective agonist of sphingosine-1-phosphate receptor 4 (S1PR4), with an EC50 of 46 nM, and has no effect on other S1P receptors at a concentration of 25 μM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $42 | In Stock | In Stock | |
| 5 mg | $67 | In Stock | In Stock | |
| 10 mg | $117 | In Stock | In Stock | |
| 25 mg | $247 | In Stock | In Stock | |
| 50 mg | $422 | In Stock | In Stock | |
| 100 mg | $628 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $75 | In Stock | In Stock |
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
Select Batch
Purity:95.92%
Contact us for more batch information
Product Introduction
ML-178 AI Summary
ML-178 is identified as a potent agonist of the Sphingosine 1-Phosphate Receptor 4 (S1P4) with an EC50 value of approximately 46 nM. It demonstrates high selectivity for S1P4, showing no significant bioactivity against S1P1, S1P2, and S1P3 receptors in respective counterscreen assays. The compound was tested in human U2OS cells, which express the S1P4 receptor along with the EDG6 gene, GAL4-VP16, and beta-arrestin/TEV protease, using a FRET-based beta-lactamase reporter gene assay to confirm its activity via nuclear migration of VP16-GAL4. Additionally, ML-178 exhibits low cytotoxicity, with a CC50 value exceeding 20,000 nM, indicating its potential safety at high concentrations..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | ML-178, a dichlorobenzene, is a potent and selective agonist of sphingosine-1-phosphate receptor 4 (S1PR4), with an EC50 of 46 nM, and has no effect on other S1P receptors at a concentration of 25 μM. |
| Targets&IC50 | S1P4 receptor:46 nM (EC50) |
| Synonyms | CYM50179 |
| Molecular Weight | 441.93 |
| Formula | C13H9Br2Cl2NO2 |
| Cas No. | 1355026-47-9 |
| Smiles | Clc1ccc(OCCOc2ccc(Br)nc2Br)c(Cl)c1 |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 15 mg/mL (33.94 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy ML-178 | purchase ML-178 | ML-178 cost | order ML-178 | ML-178 chemical structure | ML-178 formula | ML-178 molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.