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CU-CPT17e

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Catalog No. T10899Cas No. 2109805-75-4

CU-CPT17e is a potent agonist of TLR(TLR3, TLR8, and TLR9).

CU-CPT17e

CU-CPT17e

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Purity: 98.49%
Catalog No. T10899Cas No. 2109805-75-4
CU-CPT17e is a potent agonist of TLR(TLR3, TLR8, and TLR9).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$213In StockIn Stock
5 mg$441In StockIn Stock
10 mg$649In StockIn Stock
25 mg$987In StockIn Stock
50 mg$1,390-In Stock
100 mg$1,870-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:98.49%
Appearance:Solid
Color:White
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
CU-CPT17e is a potent agonist of TLR(TLR3, TLR8, and TLR9).
In vitro
The first small molecule 17e (CU-CPT17e) capable of simultaneously activating TLRs 3, 8, and 9. Biochemical studies demonstrated that 17e could induce a strong immune response via the production of various cytokines in human monocytic THP-1 cells. Furthermore, 17e inhibited the proliferation of HeLa cancer cells by triggering apoptosis and arresting the cell cycle at the S phase. These results showcase potential therapeutic applications of 17e in both vaccine adjuvants and anticancer therapies based on multi-TLR activation.
Chemical Properties
Molecular Weight504.49
FormulaC27H24N2O8
Cas No.2109805-75-4
Smiles[O-][N+](=O)c1ccc(COc2cc3OC4(CCOCC4)C=Cc3cc2OCc2ccc(cc2)[N+]([O-])=O)cc1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 2 mg/mL (3.96 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9822 mL9.9110 mL19.8220 mL99.1100 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Toll-like Receptor (TLR)TLR9TLR8TLR3TLRInhibitorinhibitCU-CPT-17eCU-CPT17eCUCPT17eCU CPT17e
Related Tags: buy CU-CPT17e | purchase CU-CPT17e | CU-CPT17e cost | order CU-CPT17e | CU-CPT17e chemical structure | CU-CPT17e in vitro | CU-CPT17e formula | CU-CPT17e molecular weight
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