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Lofexidine hydrochloride

Name: Lofexidine hydrochloride
Brand: TargetMol
SKU: T1728
Rating: 4.5 (1 reviews)

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Catalog No. T1728Cas No. 21498-08-8

Lofexidine (hydrochloride) is a selective α2-receptor agonist that is often used to relieve the physical symptoms of heroin and other types of opioid withdrawal [1] [2].

Lofexidine hydrochloride

😃Good

Catalog No. T1728Cas No. 21498-08-8

Lofexidine (hydrochloride) is a selective α2-receptor agonist that is often used to relieve the physical symptoms of heroin and other types of opioid withdrawal [1] [2].

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	Inquiry	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly

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Product Introduction

Bioactivity

Description

Lofexidine (hydrochloride) is a selective α2-receptor agonist that is often used to relieve the physical symptoms of heroin and other types of opioid withdrawal [1] [2].

Chemical Properties

Molecular Weight	295.59
Formula	C₁₁H₁₃Cl₃N₂O
Cas No.	21498-08-8
Smiles	Cl.CC(Oc1c(Cl)cccc1Cl)C1=NCCN1
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mM, Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1 mg/mL (3.38 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3831 mL	16.9153 mL	33.8306 mL	169.1532 mL
5 mM	0.6766 mL	3.3831 mL	6.7661 mL	33.8306 mL
10 mM	0.3383 mL	1.6915 mL	3.3831 mL	16.9153 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc