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OSBPL7-IN-1

🥰Excellent
Catalog No. T9565Cas No. 1269826-44-9

OSBPL7-IN-1 is an orally active inhibitor of oxysterol binding protein like 7 (OSBPL7) that promotes an increase of ABCA1 at the plasma membrane without affecting mRNA expression[1].

OSBPL7-IN-1

OSBPL7-IN-1

🥰Excellent
Purity: 99.73%
Catalog No. T9565Cas No. 1269826-44-9
OSBPL7-IN-1 is an orally active inhibitor of oxysterol binding protein like 7 (OSBPL7) that promotes an increase of ABCA1 at the plasma membrane without affecting mRNA expression[1].
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$80In StockIn Stock
5 mg$197In StockIn Stock
10 mg$313In StockIn Stock
25 mg$513In StockIn Stock
50 mg$690In StockIn Stock
100 mg$913In StockIn Stock
1 mL x 10 mM (in DMSO)$196In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.73%
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Product Introduction

Bioactivity
Description
OSBPL7-IN-1 is an orally active inhibitor of oxysterol binding protein like 7 (OSBPL7) that promotes an increase of ABCA1 at the plasma membrane without affecting mRNA expression[1].
In vitro
OSBPL7-IN-1 (compound G; 1-10?μM) increase plasma membrane ATP-binding cassette transporter (ABCA1) in cultured human podocytes, and significantly increase ABCA1-dependent cholesterol efflux[1].
In vivo
OSBPL7-IN-1 (100?mg/kg; oral gavage; daily; for 28 days) treatment normalizes proteinuria, and prevents renal function decline in mouse models of proteinuric kidney disease[1].
Chemical Properties
Molecular Weight463.28
FormulaC20H19Cl2F3N2O3
Cas No.1269826-44-9
SmilesO[C@@H]1CCCC[C@H]1NC(=O)c1cnc(OCC(F)(F)F)c(c1)-c1ccc(Cl)c(Cl)c1
Relative Density.1.46 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 11 mg/mL (23.74 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1585 mL10.7926 mL21.5852 mL107.9261 mL
5 mM0.4317 mL2.1585 mL4.3170 mL21.5852 mL
10 mM0.2159 mL1.0793 mL2.1585 mL10.7926 mL
20 mM0.1079 mL0.5396 mL1.0793 mL5.3963 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

OSBPL7-IN-1OSBPL-7-IN-1OSBPL7IN1OSBPL7 IN 1OSBPL7orally activeInhibitorinhibitABCA1
Related Tags: buy OSBPL7-IN-1 | purchase OSBPL7-IN-1 | OSBPL7-IN-1 cost | order OSBPL7-IN-1 | OSBPL7-IN-1 chemical structure | OSBPL7-IN-1 in vivo | OSBPL7-IN-1 in vitro | OSBPL7-IN-1 formula | OSBPL7-IN-1 molecular weight
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