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PD-1/PD-L1-IN-27

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Catalog No. T72680Cas No. 2891831-47-1

PD-1/PD-L1-IN-27 is a potent inhibitor of PD-1/PD-L1, with an IC50 of 134 nM, and demonstrates antitumor effects with minimal T cell cytotoxicity. It activates CD8+ T cells and mitigates T cell exhaustion [1].

PD-1/PD-L1-IN-27

PD-1/PD-L1-IN-27

😃Good
Catalog No. T72680Cas No. 2891831-47-1
PD-1/PD-L1-IN-27 is a potent inhibitor of PD-1/PD-L1, with an IC50 of 134 nM, and demonstrates antitumor effects with minimal T cell cytotoxicity. It activates CD8+ T cells and mitigates T cell exhaustion [1].
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$1,5208-10 weeks8-10 weeks
50 mg$1,9808-10 weeks8-10 weeks
100 mg$2,5008-10 weeks8-10 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
PD-1/PD-L1-IN-27 is a potent inhibitor of PD-1/PD-L1, with an IC50 of 134 nM, and demonstrates antitumor effects with minimal T cell cytotoxicity. It activates CD8+ T cells and mitigates T cell exhaustion [1].
In vitro
Administering PD-1/PD-L1-IN-27 (compound MZ58) at concentrations of 2.5, 5, 10, and 50 µM for 48 hours shows antitumor activity with minimal cytotoxicity to T cells [1].
In vivo
PD-1/PD-L1-IN-27, administered intragastrically at dosages of 10 and 25 mg/kg, exhibits an antitumor effect [1].
Chemical Properties
Molecular Weight673.75
FormulaC44H35NO6
Cas No.2891831-47-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Keywords

PD-L1PDL1PD1/PDL1PD-1PD1
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