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LEI110

Name: LEI110
Brand: TargetMol
SKU: T9753
Price: 97 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9753Cas No. 2313525-90-3

LEI110 is a potent Phospholipase A2, group XVI (PLA2G16) inhibitor with an Ki value of 20 nM. LEI110 is a selective pan-inhibitor of the HRASLS family of thiol hydrolases (i.e., PLA2G16, HRASLS2, RARRES3 and iNAT).

LEI110

🥰Excellent

Purity: 98.8%

Catalog No. T9753Cas No. 2313525-90-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$97	-	In Stock
5 mg	$213	-	In Stock
10 mg	$313	-	In Stock
25 mg	$533	-	In Stock
50 mg	$768	-	In Stock
1 mL x 10 mM (in DMSO)	$213	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.8%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	LEI110 is a potent Phospholipase A2, group XVI (PLA2G16) inhibitor with an Ki value of 20 nM. LEI110 is a selective pan-inhibitor of the HRASLS family of thiol hydrolases (i.e., PLA2G16, HRASLS2, RARRES3 and iNAT).
Targets&IC50	PLA2G16:20 nM(Ki)
In vitro	LEI110 reduces cellular arachidonic acid levels in PLA2G16-overexpressing U2OS cells and oleic acid-induced steatosis in human HepG2 cells[1].

Chemical Properties

Molecular Weight	456.46
Formula	C₂₅H₂₃F₃N₂O₃
Cas No.	2313525-90-3
Smiles	FC(F)(F)c1ccc(Oc2ccc(CCNC(=O)C(=O)CCCc3ccccc3)cc2)nc1
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (109.54 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (5.48 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1908 mL	10.9539 mL	21.9077 mL	109.5386 mL
5 mM	0.4382 mL	2.1908 mL	4.3815 mL	21.9077 mL
10 mM	0.2191 mL	1.0954 mL	2.1908 mL	10.9539 mL
20 mM	0.1095 mL	0.5477 mL	1.0954 mL	5.4769 mL
50 mM	0.0438 mL	0.2191 mL	0.4382 mL	2.1908 mL
100 mM	0.0219 mL	0.1095 mL	0.2191 mL	1.0954 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc