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Kif15-IN-1

🥰Excellent
Catalog No. T15661Cas No. 672926-32-8

Kif15-IN-1 is a kinesin family 15 (Kif15) inhibitor with antiproliferative activity and potential anticancer activity, which can be used to study gastric cancer.

Kif15-IN-1

Kif15-IN-1

🥰Excellent
Purity: 99.39%
Catalog No. T15661Cas No. 672926-32-8
Kif15-IN-1 is a kinesin family 15 (Kif15) inhibitor with antiproliferative activity and potential anticancer activity, which can be used to study gastric cancer.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$499-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.39%
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Product Introduction

Bioactivity
Description
Kif15-IN-1 is a kinesin family 15 (Kif15) inhibitor with antiproliferative activity and potential anticancer activity, which can be used to study gastric cancer.
In vitro
Concentration response analysis using the MT gliding assay revealed that the IC50 was 203 nM, significantly lower than the previous study. Concentration response curve using the MT-gliding assay, developed from 5 concentrations of Kif15-IN-1, ranging from 30 to 0.1 µM.
Kif15-IN-1 is a competitive ATP inhibitor. Double reciprocal Lineweaver-Burk plot of ATP titration using 5 µM Kif15-IN-1. An increase in KMATP was observed when the ATP concentration was varied in the presence of Kif15-IN-1, indicating that Kif15-IN-1 competes with ATP binding. [1]
Chemical Properties
Molecular Weight430.48
FormulaC20H22N4O5S
Cas No.672926-32-8
Smiles[C@@H](C(NC=1SC(C(OCC)=O)=C(C)N1)=O)([C@H](C)C)N2C(=O)C=3C(NC2=O)=CC=CC3
Relative Density.1.361 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: < 0.1 mg/mL (insoluble)
DMSO: 80 mg/mL (185.84 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.67 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3230 mL11.6149 mL23.2299 mL116.1494 mL
5 mM0.4646 mL2.3230 mL4.6460 mL23.2299 mL
10 mM0.2323 mL1.1615 mL2.3230 mL11.6149 mL
20 mM0.1161 mL0.5807 mL1.1615 mL5.8075 mL
50 mM0.0465 mL0.2323 mL0.4646 mL2.3230 mL
100 mM0.0232 mL0.1161 mL0.2323 mL1.1615 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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% Saline/PBS/ddH2O

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Kif15-IN-1Kif-15-IN-1Kif15IN1Kif15 IN 1Kif15KIF15
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