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Kif15-IN-1

Name: Kif15-IN-1
Brand: TargetMol
SKU: T15661
Price: 499 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15661Cas No. 672926-32-8

Kif15-IN-1 is a kinesin family 15 (Kif15) inhibitor with antiproliferative activity and potential anticancer activity, which can be used to study gastric cancer.

Kif15-IN-1

🥰Excellent

Purity: 99.39%

Catalog No. T15661Cas No. 672926-32-8

Kif15-IN-1 is a kinesin family 15 (Kif15) inhibitor with antiproliferative activity and potential anticancer activity, which can be used to study gastric cancer.

Pack Size	Price	Availability	Quantity
1 mg	$499	In Stock

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Purity:99.39%

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Product Introduction

Bioactivity

Description

Kif15-IN-1 is a kinesin family 15 (Kif15) inhibitor with antiproliferative activity and potential anticancer activity, which can be used to study gastric cancer.

In vitro

Concentration response analysis using the MT gliding assay revealed that the IC50 was 203 nM, significantly lower than the previous study. Concentration response curve using the MT-gliding assay, developed from 5 concentrations of Kif15-IN-1, ranging from 30 to 0.1 µM.
Kif15-IN-1 is a competitive ATP inhibitor. Double reciprocal Lineweaver-Burk plot of ATP titration using 5 µM Kif15-IN-1. An increase in KMATP was observed when the ATP concentration was varied in the presence of Kif15-IN-1, indicating that Kif15-IN-1 competes with ATP binding. [1]

Chemical Properties

Molecular Weight	430.48
Formula	C₂₀H₂₂N₄O₅S
Cas No.	672926-32-8
Smiles	[C@@H](C(NC=1SC(C(OCC)=O)=C(C)N1)=O)([C@H](C)C)N2C(=O)C=3C(NC2=O)=CC=CC3
Relative Density.	1.361 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: < 0.1 mg/mL (insoluble)

DMSO: 80 mg/mL (185.84 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3230 mL	11.6149 mL	23.2299 mL	116.1494 mL
5 mM	0.4646 mL	2.3230 mL	4.6460 mL	23.2299 mL
10 mM	0.2323 mL	1.1615 mL	2.3230 mL	11.6149 mL
20 mM	0.1161 mL	0.5807 mL	1.1615 mL	5.8075 mL
50 mM	0.0465 mL	0.2323 mL	0.4646 mL	2.3230 mL
100 mM	0.0232 mL	0.1161 mL	0.2323 mL	1.1615 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc