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Kif15-IN-1

Name: Kif15-IN-1
Brand: TargetMol
SKU: T15661
Price: 499 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15661Cas No. 672926-32-8

Kif15-IN-1 is a kinesin family 15 (Kif15) inhibitor with antiproliferative activity and potential anticancer activity, which can be used to study gastric cancer.

Kif15-IN-1

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Purity: 99.39%

Catalog No. T15661Cas No. 672926-32-8

Kif15-IN-1 is a kinesin family 15 (Kif15) inhibitor with antiproliferative activity and potential anticancer activity, which can be used to study gastric cancer.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$499	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.39%

Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description

Kif15-IN-1 is a kinesin family 15 (Kif15) inhibitor with antiproliferative activity and potential anticancer activity, which can be used to study gastric cancer.

In vitro

Concentration response analysis using the MT gliding assay revealed that the IC50 was 203 nM, significantly lower than the previous study. Concentration response curve using the MT-gliding assay, developed from 5 concentrations of Kif15-IN-1, ranging from 30 to 0.1 µM.
Kif15-IN-1 is a competitive ATP inhibitor. Double reciprocal Lineweaver-Burk plot of ATP titration using 5 µM Kif15-IN-1. An increase in KMATP was observed when the ATP concentration was varied in the presence of Kif15-IN-1, indicating that Kif15-IN-1 competes with ATP binding. [1]

Chemical Properties

Molecular Weight	430.48
Formula	C₂₀H₂₂N₄O₅S
Cas No.	672926-32-8
Smiles	[C@@H](C(NC=1SC(C(OCC)=O)=C(C)N1)=O)([C@H](C)C)N2C(=O)C=3C(NC2=O)=CC=CC3
Relative Density.	1.361 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 0.1 mg/mL (insoluble)

DMSO: 80 mg/mL (185.84 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.67 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3230 mL	11.6149 mL	23.2299 mL	116.1494 mL
5 mM	0.4646 mL	2.3230 mL	4.6460 mL	23.2299 mL
10 mM	0.2323 mL	1.1615 mL	2.3230 mL	11.6149 mL
20 mM	0.1161 mL	0.5807 mL	1.1615 mL	5.8075 mL
50 mM	0.0465 mL	0.2323 mL	0.4646 mL	2.3230 mL
100 mM	0.0232 mL	0.1161 mL	0.2323 mL	1.1615 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc