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OAC1

Name: OAC1
Brand: TargetMol
SKU: T2040
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2040Cas No. 300586-90-7

Alias BAS 00287861

OAC1 (BAS 00287861) is a compound activating Octamer-binding transcription factor 4 (Oct4). It enhances the iPSC reprogramming efficiency and accelerates the reprogramming process.

OAC1

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Purity: 99.65%

Catalog No. T2040Alias BAS 00287861Cas No. 300586-90-7

OAC1 (BAS 00287861) is a compound activating Octamer-binding transcription factor 4 (Oct4). It enhances the iPSC reprogramming efficiency and accelerates the reprogramming process.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$31	In Stock	In Stock
2 mg	$42	In Stock	In Stock
5 mg	$64	In Stock	In Stock
10 mg	$98	In Stock	In Stock
25 mg	$176	In Stock	In Stock
50 mg	$333	In Stock	In Stock
100 mg	$600	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$64	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.65%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	OAC1 (BAS 00287861) is a compound activating Octamer-binding transcription factor 4 (Oct4). It enhances the iPSC reprogramming efficiency and accelerates the reprogramming process.
In vivo	OAC1 appears to enhance reprogramming efficiency by increasing transcription of the Oct4-Nanog-Sox2 triad and Tet1, a gene known to be involved in DNA demethylation. OAC1 does not inhibit the p53-p21 pathway or activate Wnt-β-catenin signaling.OAC1 can be used to enhance the reprogramming of somatic cells to a pluripotent state.1 μM OAC1 enhances the reprogramming efficiency by activating the Oct4 and Nanog promoter-driven luciferase reporter genes. In addition, OAC1 enhanced the reprogramming efficiency and accelerated the reprogramming process of pluripotent stem cells (iPSCs) in mouse embryonic fibroblasts (MEFs) treated with four reprogramming factors (Oct4, Sox2, c-Myc and Klf4).
Kinase Assay	Enzymology: Kinesin motor domains are expressed in Escherichia coli BL21(DE3) and purified. CENP-E proteins includes residues 2–340 with a carboxyl-terminal 6-his tag. All studies using MT are conducted in PEM25 buffer [25 mM PipesK+ (pH 6.8), 2 mM MgCl2, 1 mM EGTA] supplemented with 10 μM paclitaxel. The IC50 for steady-state inhibition is determined at 500 μM ATP, 5 μM MT, and 1 nM CENP-E in PEM25 buffer.
Cell Research	The Oct4-luc or Nanog-luc cells are treated with compound OAC1 at 1 μM concentration. Luciferase reporter assays are performed 24 h after OAC1 treatment.(Only for Reference)
Synonyms	BAS 00287861

Chemical Properties

Molecular Weight	237.26
Formula	C₁₄H₁₁N₃O
Cas No.	300586-90-7
Smiles	O=C(Nc1cc2cc[nH]c2cn1)c1ccccc1
Relative Density.	1.363 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 23.7 mg/mL (99.89 mM), Sonication is recommended.

DMSO: 23.7 mg/mL (99.89 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.43 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2148 mL	21.0739 mL	42.1479 mL	210.7393 mL
5 mM	0.8430 mL	4.2148 mL	8.4296 mL	42.1479 mL
10 mM	0.4215 mL	2.1074 mL	4.2148 mL	21.0739 mL
20 mM	0.2107 mL	1.0537 mL	2.1074 mL	10.5370 mL
50 mM	0.0843 mL	0.4215 mL	0.8430 mL	4.2148 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc