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Anti-Phospho-Rad17 (Ser656) Antibody (7H829)
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Catalog No. TMAB-11207
Anti-Phospho-Rad17 (Ser656) Antibody (7H829) is a Rabbit antibody targeting Phospho-Rad17 (Ser656). Anti-Phospho-Rad17 (Ser656) Antibody (7H829) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF.
Anti-Phospho-Rad17 (Ser656) Antibody (7H829)
Anti-Phospho-Rad17 (Ser656) Antibody (7H829)
Copy Product Info😃Good
Catalog No. TMAB-11207
Anti-Phospho-Rad17 (Ser656) Antibody (7H829) is a Rabbit antibody targeting Phospho-Rad17 (Ser656). Anti-Phospho-Rad17 (Ser656) Antibody (7H829) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $151 | 7-10 days | 7-10 days | |
| 50 μL | $263 | 7-10 days | 7-10 days | |
| 100 μL | $470 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Anti-Phospho-Rad17 (Ser656) Antibody (7H829) is a Rabbit antibody targeting Phospho-Rad17 (Ser656). Anti-Phospho-Rad17 (Ser656) Antibody (7H829) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF. |
| Ig Type | IgG |
| Clone | 7H829 |
| Reactivity | Human |
| Verified Activity | Western blot analysis of (1) HeLa cell treated with CA lysate; (2) HeLa cell lysate. Using Phospho-Rad17 (Ser656) (TMAB-11207) monoclonal antibody at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r. T. for 60 min. |
| Application | |
| Recommended Dose | WB: 1:1000-2000; IHC-P: 1:100-200; IHC-Fr: 1:100-200; ICC/IF: 1:50-200; IF: 1:50-200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. Note=Phosphorylated form redistributes to discrete nuclear foci upon DNA damage. |
| Tissue Specificity | Overexpressed in various cancer cell lines and in colon carcinoma (at protein level). Isoform 2 and isoform 3 are the most abundant isoforms in non irradiated cells (at protein level). Ubiquitous at low levels. Highly expressed in testis, where it is expressed within the germinal epithelium of the seminiferous tubuli. Weakly expressed in seminomas (testicular tumors). |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| Research Background | Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. |
| Immunogen | A synthesized peptide: human RAD17 around the phosphorylation site of S656 |
| Antigen Species | Human |
| Gene Name | RAD17 |
| Gene ID | |
| Protein Name | Cell cycle checkpoint protein RAD17 |
| Uniprot ID | |
| Function | Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9-HUS1 complex and C12orf32/RHINO onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination. |
| Molecular Weight | Theoretical: 77 kDa. Actual: 85 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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