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Norchlorcyclizine

Name: Norchlorcyclizine
Brand: TargetMol
SKU: T20499
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20499Cas No. 303-26-4

Alias C-10, C10, C 10

Norchlorcyclizine (C-10) is a partially selective NPR-B inhibitor. It also is an inhibitor of human tyrosyl-DNA phosphodiesterase 1.

Norchlorcyclizine

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Purity: 97.27%

Catalog No. T20499Alias C-10, C10, C 10Cas No. 303-26-4

Norchlorcyclizine (C-10) is a partially selective NPR-B inhibitor. It also is an inhibitor of human tyrosyl-DNA phosphodiesterase 1.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:97.27%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Norchlorcyclizine AI Summary

Norchlorcyclizine exhibits a range of bioactivities, including significant dose-dependent inhibition of trypanothione reductase activity, with the highest inhibition of 40.0% at 57 µM and no inhibition observed at 5.7 µM. It possesses potent antiviral activity against HCV in Huh7.5.1 cells with an EC50 of 35.0 nM and a selectivity index of 297.0. The compound also demonstrates cytotoxicity with a CC50 of 10400.0 nM in the same cell line. Norchlorcyclizine inhibits a variety of proteins and enzymes, including Influenza NS1, AmpC Beta-Lactamase, N370S glucocerebrosidase, and mammalian Selenoprotein Thioredoxin Reductase 1, among others, indicating possible therapeutic effects in related diseases. It has a LogD7.4 of 1.94, and a high plasma protein binding rate of 94.19%, implying moderate to high lipophilicity and strong plasma protein binding, which could affect its distribution and metabolism. Additionally, Norchlorcyclizine acts as an agonist in human TLX LBD and full-length TLX activating elements, showing specific changes in reporter activities and stabilization effects..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Norchlorcyclizine (C-10) is a partially selective NPR-B inhibitor. It also is an inhibitor of human tyrosyl-DNA phosphodiesterase 1.
Synonyms	C-10, C10, C 10

Chemical Properties

Molecular Weight	286.8
Formula	C₁₇H₁₉ClN₂
Cas No.	303-26-4
Smiles	ClC1=CC=C(C=C1)C(N1CCNCC1)C1=CC=CC=C1
Relative Density.	1.158 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 65 mg/mL (226.64 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4868 mL	17.4338 mL	34.8675 mL	174.3375 mL
5 mM	0.6974 mL	3.4868 mL	6.9735 mL	34.8675 mL
10 mM	0.3487 mL	1.7434 mL	3.4868 mL	17.4338 mL
20 mM	0.1743 mL	0.8717 mL	1.7434 mL	8.7169 mL
50 mM	0.0697 mL	0.3487 mL	0.6974 mL	3.4868 mL
100 mM	0.0349 mL	0.1743 mL	0.3487 mL	1.7434 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc