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GSK-5959

Name: GSK-5959
Brand: TargetMol
SKU: T1972
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T1972Cas No. 901245-65-6

GSK-5959 is an effective, specific and cell permeable BRPF1 bromodomain inhibitor (IC50: ~80 nM). The selectivity of GSK-5959 for BRPF1 is >100-fold over a panel of 35 other bromodomains, including BRPF2/3 and BET family bromodomains.

GSK-5959

🥰Excellent

Purity: 98.65%

Catalog No. T1972Cas No. 901245-65-6

Pack Size	Price	Availability
5 mg	$52	In Stock
10 mg	$89	In Stock
25 mg	$159	In Stock
50 mg	$263	In Stock
100 mg	$392	In Stock
200 mg	$573	In Stock
1 mL x 10 mM (in DMSO)	$58	In Stock

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Batch Information

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Purity:98.65%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	GSK-5959 is an effective, specific and cell permeable BRPF1 bromodomain inhibitor (IC50: ~80 nM). The selectivity of GSK-5959 for BRPF1 is >100-fold over a panel of 35 other bromodomains, including BRPF2/3 and BET family bromodomains.
Targets&IC50	BRPF1:80 nM

Chemical Properties

Molecular Weight	394.47
Formula	C₂₂H₂₆N₄O₃
Cas No.	901245-65-6
Smiles	COc1ccccc1C(=O)Nc1cc2n(C)c(=O)n(C)c2cc1N1CCCCC1
Relative Density.	1.263 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (25.35 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5350 mL	12.6752 mL	25.3505 mL	126.7524 mL
5 mM	0.5070 mL	2.5350 mL	5.0701 mL	25.3505 mL
10 mM	0.2535 mL	1.2675 mL	2.5350 mL	12.6752 mL
20 mM	0.1268 mL	0.6338 mL	1.2675 mL	6.3376 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc