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CP 465022

Catalog No. T21584   CAS 199655-36-2

CP 465022 hydrochloride is a potent, and selective noncompetitive antagonist of AMPA receptor with anticonvulsant activity. CP 465022 hydrochloride inhibits Kainate-induced response with an IC50 of 25 nM in rat cortical neurons.

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CP 465022 Chemical Structure
CP 465022, CAS 199655-36-2
Pack Size Availability Price/USD Quantity
1 mg In stock $ 34.00
5 mg In stock $ 80.00
10 mg In stock $ 128.00
25 mg In stock $ 278.00
50 mg In stock $ 488.00
100 mg In stock $ 698.00
1 mL * 10 mM (in DMSO) In stock $ 98.00
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Purity: 98.75%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description CP 465022 hydrochloride is a potent, and selective noncompetitive antagonist of AMPA receptor with anticonvulsant activity. CP 465022 hydrochloride inhibits Kainate-induced response with an IC50 of 25 nM in rat cortical neurons.
Targets&IC50 Kainate-induced response:25 nM (rat cortical neurons)
In vitro CP 465022 hydrochloride 1 µM for 10 min has little effect on peak NMDA-induced currents but reduces current measured at 8 s during NMDA application by 26%.CP-465,022 at 10 µM inhibits peak NMDA-induced currents in cortical neurons by 36% and currents measured at 8 s by 70% d in primary cultures of cortical and cerebellar granule neurons. CP 465022 hydrochloride (0.0001 μM-10 μM) inhibits kainate-induced response in relatively slow manner and dependents on compound concentration, exhibiting a calculated IC50 of 25 nM and essentially complete inhibition at 3.2 µM. CP 465022 hydrochloride 1 µM for 10 min inhibits peak NMDA currents in cultured rat cerebellar granule neurons with mean inhibition of 19% and NMDA currents measured at 8 s by 45%, similar to what is observed in the cortical neurons. CP 465022 hydrochloride (100 nM -10 µM) has inhibitory effects on Kainate-induced whole-cell currents in voltage-clamped rat hippocampal, 100 nM CP465,022 inhibits kainate currents developed over the course of 200s, 500 nM and 1 µM CP-465,022 nearly complete inhibits this time frame (99.3%)[1].
Molecular Weight 462.95
Formula C26H24ClFN4O
CAS No. 199655-36-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 4.63 mg/mL (10 mM)

TargetMolReferences and Literature

1. J T Lazzaro, et al. Functional characterization of CP-465,022, a selective, noncompetitive AMPA receptor antagonist. Neuropharmacology. 2002 Feb;42(2):143-53.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compounds Library Max Bioactive Compound Library Neuronal Signaling Compound Library

Related Products

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AMPA receptor antagonist-2 PEPA 1-BCP AMPA receptor modulator-1 Dizocilpine D-Serine CGP 37849 Gavestinel

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Keywords

CP 465022 199655-36-2 Membrane transporter/Ion channel Neuroscience iGluR CP 465022 hydrochloride CP465022 CP-465022 inhibitor inhibit

 

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