This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
Antitubercular agent-27
Catalog No. T61141 CAS
2460651-09-4
Antitubercular agent-27 (compound 1) exhibits potent antitubercular properties, demonstrated by an IC50 of 3.2 μM, an MIC of 7.8 μM, and an IC90 of 7.0 μM. It effectively targets resistant Mycobacterium tuberculosis H37Rv isolates, displaying significant intracellular antimycobacterial activity with low cytotoxicity [1].
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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
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Biological Description
Chemical Properties
Storage
& Solubility Information
Description
Antitubercular agent-27 (compound 1) exhibits potent antitubercular properties, demonstrated by an IC50 of 3.2 μM, an MIC of 7.8 μM, and an IC90 of 7.0 μM. It effectively targets resistant Mycobacterium tuberculosis H37Rv isolates, displaying significant intracellular antimycobacterial activity with low cytotoxicity [1].
In vitro
Antitubercular agent-27 (compound 1) shows antimycobacterial activity for resistant isolates of M. tuberculosis H37Rv with IC 50 s of 2.4, 100, 120, 1.3, 3.1 μM, MICs of 3.2, 140, 160, 2.4, 4.2 μM, IC 90 s of 3.0, 120, 142, 2.2, 3.5 μM for FQ-R1, INH-R1, INH-R2, RIF-R1, RIF-R2, respectively [1]. Antitubercular agent-27 (0-200 μM) shows antibacterial activity with an MIC value of 0.80 μM, IC 50 value of 0.23 μM, and IC 90 value of 0.43 μM in low oxygen condition, and an MIC value of 0.45 μM, IC 50 value of 0.27 μM, and IC 90 value of 0.35 μM in normal oxygen condition [1]. Antitubercular agent-27 (0-200 μM) shows intracellular activity with an IC 50 value of 1.45 μM, and IC 90 value of 1.61 μM, and low cytotoxicity with an IC 50 value of >100 μM [1].
Molecular Weight
346.14
Formula
C14H8BrN3O3
CAS No.
2460651-09-4
Storage
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dose Conversion
You can also refer to dose conversion for different animals.
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Method for preparing DMSO master liquid: mg
drug pre-dissolved in μL DMSO (Master liquid concentration
mg/mL),
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL PEG300, mix and clarify, next add μL
Tween 80,mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL Corn oil,mix and clarify.
Note:
Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.