Powder: -20°C for 3 years
In solvent: -80°C for 2 years
CINPA1 is a selective inhibitor of constitutive androstane receptor (CAR) with an IC50 of 70 nM for CAR-mediated transcription. CINPA1 can be used in studies about CAR function.
Description | CINPA1 is a selective inhibitor of constitutive androstane receptor (CAR) with an IC50 of 70 nM for CAR-mediated transcription. CINPA1 can be used in studies about CAR function. |
Targets&IC50 | CAR:~70 nM |
In vitro | CINPA1 is a specific xenobiotic receptor inhibitor and has no cytotoxic effects up to 30 μM. CINPA1 inhibits CAR-mediated gene expression in primary human hepatocytes, where CAR is endogenously expressed and it efficiently inhibits CAR-LBD interaction with the coactivator peptide. CINPA1 (1μM) inhibits CAR-mediated transactivation without activating the pregnane X receptor (PXR) in HepG2 cells. In mammalian two-hybrid assays, CINPA1 increases the corepressor and reduces coactivator interaction with the CAR ligand-binding domain. In chromatin immunoprecipitation assays, CINPA1 disrupts CAR binding to the promoter regions of target genes[1]. |
Synonyms | CINPA-1, CINPA 1 |
Molecular Weight | 395.49 |
Formula | C23H29N3O3 |
CAS No. | 102636-74-8 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 200 mg/mL (505.7 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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CINPA1 102636-74-8 Others CINPA-1 CINPA 1 Inhibitor inhibitor inhibit