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CINPA1

Catalog No. T14969 CAS 102636-74-8

Synonyms: CINPA-1, CINPA 1

CINPA1 is a selective inhibitor of constitutive androstane receptor (CAR) with an IC50 of 70 nM for CAR-mediated transcription. CINPA1 can be used in studies about CAR function.

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CINPA1, CAS 102636-74-8

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Purity: 98%

Biological Description

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Description	CINPA1 is a selective inhibitor of constitutive androstane receptor (CAR) with an IC50 of 70 nM for CAR-mediated transcription. CINPA1 can be used in studies about CAR function.
Targets&IC50	CAR:~70 nM
In vitro	CINPA1 is a specific xenobiotic receptor inhibitor and has no cytotoxic effects up to 30 μM. CINPA1 inhibits CAR-mediated gene expression in primary human hepatocytes, where CAR is endogenously expressed and it efficiently inhibits CAR-LBD interaction with the coactivator peptide. CINPA1 (1μM) inhibits CAR-mediated transactivation without activating the pregnane X receptor (PXR) in HepG2 cells. In mammalian two-hybrid assays, CINPA1 increases the corepressor and reduces coactivator interaction with the CAR ligand-binding domain. In chromatin immunoprecipitation assays, CINPA1 disrupts CAR binding to the promoter regions of target genes[1].

Synonyms	CINPA-1, CINPA 1
Molecular Weight	395.49
Formula	C23H29N3O3
CAS No.	102636-74-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 200 mg/mL (505.7 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Cherian MT, et al. CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor. Mol Pharmacol. 2015 May;87(5):878-89.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CINPA1 102636-74-8 Others CINPA-1 CINPA 1 Inhibitor inhibitor inhibit

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