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Anti-14-3-3 beta/alpha Antibody (7X437)

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Catalog No. TMAC-00005

Anti-14-3-3 beta/alpha Antibody (7X437) is a Rabbit antibody targeting 14-3-3 beta/alpha. Anti-14-3-3 beta/alpha Antibody (7X437) can be used in WB,IHC.

Anti-14-3-3 beta/alpha Antibody (7X437)

Anti-14-3-3 beta/alpha Antibody (7X437)

😃Good
Catalog No. TMAC-00005
Anti-14-3-3 beta/alpha Antibody (7X437) is a Rabbit antibody targeting 14-3-3 beta/alpha. Anti-14-3-3 beta/alpha Antibody (7X437) can be used in WB,IHC.
Pack SizePriceAvailabilityQuantity
50 μL$2977-10 days
100 μL$4987-10 days
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Product Introduction

Bioactivity
Description
Anti-14-3-3 beta/alpha Antibody (7X437) is a Rabbit antibody targeting 14-3-3 beta/alpha. Anti-14-3-3 beta/alpha Antibody (7X437) can be used in WB,IHC.
Ig Type
IgG
Reactivity
Human,Mouse,Rat
Application
Recommended Dose
WB: 1:1000-2000; IHC: 1:50-200
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionRecombinant Antibody
PurificationProA affinity purified
AppearanceLiquid
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Research BackgroundThe 14-3-3 family of proteins are important regulatory molecules ubiquitiously expressed in all eukarryotic cells which bind to numerous signaling proteins in various pathways driving critical cellular pathways of apoptosis, differentiation and cell cycle. 14-3-3 theta specifically has also been shown to play an important regulatory role in the TLR2 signaling pathways as a negative regulator of TLR2 ligand Pam3CySk4 induced NF-kB activation. 14-3-3 theta has previously been shown to interact with TLR4 ligand and MyD88 dependent phosphorylated PkC epsilon. 14-3-3 theta in the TLR4 signaling pathway is a positive regulator controlling release of IRF3 indcuded pro-inflammatory cytokines RANTES and IP-10. Currently identified by mass spec as part of the TLR2 signaling complex and taken along with TLR4 data, a 14-3-3 theta antibody can be used to examine the different regulatory functions of 14-3-3 theta for different TLRs through its interaction with common or unique TLR signaling adaptor molecules in addition to MyD88 or PkC epsilon such as TRAM or TRIF allowing further clarification of TLR specific pathway regulation.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
49227
Antigen Species
Recombinant Protein
Uniprot ID
Chemical Properties
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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