Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IHMT-EZH2-426 (compound 38) is a potent, covalent degrader of EZH2, demonstrating IC50 values of 1.3 nM for EZH2 wild-type, 1.2 nM for EZH2-A687V, and 1.7-3.5 nM for EZH2-Y641F/Y641N/Y641S mutants. The compound effectively inhibits proliferation in B-cell lymphoma and triple-negative breast cancer (TNBC) cell lines, attributed to its capacity to diminish H3K27me3 and EZH2 levels [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | Inquiry | |
50 mg | Inquiry | Inquiry |
Description | IHMT-EZH2-426 (compound 38) is a potent, covalent degrader of EZH2, demonstrating IC50 values of 1.3 nM for EZH2 wild-type, 1.2 nM for EZH2-A687V, and 1.7-3.5 nM for EZH2-Y641F/Y641N/Y641S mutants. The compound effectively inhibits proliferation in B-cell lymphoma and triple-negative breast cancer (TNBC) cell lines, attributed to its capacity to diminish H3K27me3 and EZH2 levels [1]. |
Targets&IC50 | EZH2 WT:1.3 nM, EZH2-A687V:1.2 nM, Y641F/Y641N/Y641S:1.7-3.5 nM |
Molecular Weight | 578.7 |
Formula | C31H35FN4O4S |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
IHMT-EZH2-426 Chromatin/Epigenetic Histone Methyltransferase inhibitor inhibit