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Flavin adenine dinucleotide

Catalog No. T65172 CAS 146-14-5

Synonyms: FAD

Flavin adenine dinucleotide (FAD) is a REDOX cofactor, a protein cogroup, involved in a variety of metabolic reactions.

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Flavin adenine dinucleotide Chemical Structure

Flavin adenine dinucleotide, CAS 146-14-5

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1 mg	In stock	$ 30.00
5 mg	In stock	$ 41.00
10 mg	In stock	$ 59.00
25 mg	In stock	$ 98.00
50 mg	In stock	$ 143.00
100 mg	In stock	$ 213.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Flavin adenine dinucleotide (FAD) is a REDOX cofactor, a protein cogroup, involved in a variety of metabolic reactions.
In vitro	Characterized by an additional polymer-type redox reaction, Poly(Flavin adenine dinucleotide, FAD) is a highly effective electrocatalyst for NADH oxidation. Operating at the lowest potentials reported for NADH transducers (0.00 V, pH 7.4), poly(FAD) exhibits an electrochemical rate constant of 1.8 ± 0.6×10-3 cm/s, which is at the level of the NADH mass-transfer constant. Poly(FAD)-modified electrodes demonstrate dramatically improved stability and are the most advantageous NADH transducers for analytical chemistry[2].
In vivo	Administered intravenously at a dose of 2 mg/kg, Flavin adenine dinucleotide significantly cancels the chlorpromazine (CPZ)-induced decrease in ventricular fibrillation threshold (VFT). The effect of CPZ on canine heart mitochondria is nullified by Flavin adenine dinucleotide. Following the injection of Flavin adenine dinucleotide, the dogs experience a transient hypotension within 10 minutes, after which their blood pressures recover to the initial level. Additionally, Flavin adenine dinucleotide prevents mitochondrial dysfunction induced by chlorpromazine[1].

Synonyms	FAD
Molecular Weight	785.55
Formula	C27H33N9O15P2
CAS No.	146-14-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 100 mg/mL (127.30 mM), Sonication is recommended.

References and Literature

1. Sugiyama S, et al. Protection of chlorpromazine-induced arrhythmia by flavin-adenine-dinucleotide in canine heart. Jpn Heart J. 1979 Sep;20(5):657-65. 2. Karyakin AA, et al. Electropolymerized flavin adenine dinucleotide as an advanced NADH transducer. Anal Chem. 2004 Apr 1;76(7):2004-9.

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Keywords

Flavin adenine dinucleotide 146-14-5 Metabolism Endogenous Metabolite FAD inhibitor inhibit

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