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Anti-PPM1A Antibody-PE (9X611)
🥰Excellent
Catalog No. TMAY-02428P
Anti-PPM1A Antibody-PE (9X611) is a PE-conjugated Mouse antibody targeting PPM1A. Anti-PPM1A Antibody-PE (9X611) can be used in FCM.
Anti-PPM1A Antibody-PE (9X611)
Anti-PPM1A Antibody-PE (9X611)
🥰Excellent
Catalog No. TMAY-02428P
Anti-PPM1A Antibody-PE (9X611) is a PE-conjugated Mouse antibody targeting PPM1A. Anti-PPM1A Antibody-PE (9X611) can be used in FCM.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-PPM1A Antibody-PE (9X611) is a PE-conjugated Mouse antibody targeting PPM1A. Anti-PPM1A Antibody-PE (9X611) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG2a |
| Clone | 9X611 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human PPM1A expression in Jurkat cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), and then stained with PE Mouse anti-Human PPM1A. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | FCM |
| Recommended Dose | 10 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human PPM1A / PP2C-alpha (rh PPM1A / PP2C-alpha; TMPY-02567; P35813-1; Met1-Trp382) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| Research Background | Protein phosphatase 1A (PPM1A / PP2CA) is an enzyme belonging to the PP2C family of Ser / Thr protein phosphatases. Members of PP2C family are negative regulators of cell stress response pathways and the MAP kinases and MAP kinase kinases. It has also been demonstrated to inhibit the activation of p38 and JNK kinase cascades. PPM1A dephosphorylates and promotes nuclear export of TGFβ-activated Smad2/3. Ectopic expression of PPM1A abolishes TGFβ-induced antiproliferative and transcriptional responses, whereas depletion of PPM1A enhances TGFβ signaling in mammalian cells. It has been demonstrated that PPM1A / PP2CA, through dephosphorylation of Smad2/3, plays a critical role in terminating TGFβ signaling. Overexpression of PPM1A is reported to activate the expression of the tumor suppressor gene TP53 / p53, which leads to cell apoptosis. |
| Conjucates | PE |
| Others Formats | Unconjugated/FITC |
| Antibody Types Available | 3 |
| Immunogen | Recombinant Human PPM1A / PP2C-alpha protein (TMPY-02567) |
| Antigen Species | Human |
| Biology Area | Phosphatases and Regulators |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| Transport | Shipping with blue ice. |
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