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Probucol

Name: Probucol
Brand: TargetMol
SKU: T0254
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0254Cas No. 23288-49-5

Alias DH-581

Probucol (DH-581), an anti-hyperlipidemic drug, can lower the level of cholesterol in the bloodstream by increasing the LDL catabolic rate.

Probucol

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Purity: 99.95%

Catalog No. T0254Alias DH-581Cas No. 23288-49-5

Probucol (DH-581), an anti-hyperlipidemic drug, can lower the level of cholesterol in the bloodstream by increasing the LDL catabolic rate.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$31	In Stock	In Stock
50 mg	$42	In Stock	In Stock
100 mg	$58	In Stock	In Stock
500 mg	$81	In Stock	In Stock
1 g	$118	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$35	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.95%

Color:White

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COA LCMS HNMR

Product Introduction

Probucol AI Summary

Probucol exhibits a multifaceted profile of bioactivities, prominently characterized by its potential antioxidant and hypolipidemic properties. It effectively reduces total serum cholesterol, triglycerides, and low-density lipoprotein (LDL) levels in various animal models, including WHHL rabbits and Sprague-Dawley rats. The compound demonstrates significant activity in preventing Cu2+-induced lipid peroxidation in serum and LDL particles, with IC50 values ranging from 500 to 5300 nM. Additionally, it shows concentration-dependent inhibition of LDL oxidation induced by copper and macrophage-mediated processes, displaying IC50 values indicative of strong antioxidative capabilities. Probucol also exhibits free radical scavenging activity, with an SC50 of 21.67 µM in DPPH assays, and moderate inhibition of MCLA chemiluminescence. Despite its antioxidative efficiency, the compound's oral bioavailability is less than 20%, suggesting challenges in absorption or extensive metabolism. Furthermore, its calculated partition coefficient (cLogP) of 10.75 and logD6.5 of 7.29 indicate high lipophilicity. Toxicological evaluations have revealed a substantial difference in toxicity between intravenous (LD50 of 25.0 mg/kg in mice) and oral administration (LD50 > 5000 mg/kg). However, it shows no significant acute or chronic hepatotoxicity. These comprehensive bioactivity profiles make Probucol a promising candidate for therapeutic applications targeting dyslipidemia and oxidative stress, while considerations for its delivery and long-term safety remain essential..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Probucol (DH-581), an anti-hyperlipidemic drug, can lower the level of cholesterol in the bloodstream by increasing the LDL catabolic rate.
Synonyms	DH-581

Chemical Properties

Molecular Weight	516.84
Formula	C₃₁H₄₈O₂S₂
Cas No.	23288-49-5
Smiles	CC(C)(SC1=CC(=C(O)C(=C1)C(C)(C)C)C(C)(C)C)SC1=CC(=C(O)C(=C1)C(C)(C)C)C(C)(C)C
Relative Density.	1.07 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (483.71 mM), Sonication is recommended.

Ethanol: 95 mg/mL (183.81 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.87 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9348 mL	9.6742 mL	19.3483 mL	96.7417 mL
5 mM	0.3870 mL	1.9348 mL	3.8697 mL	19.3483 mL
10 mM	0.1935 mL	0.9674 mL	1.9348 mL	9.6742 mL
20 mM	0.0967 mL	0.4837 mL	0.9674 mL	4.8371 mL
50 mM	0.0387 mL	0.1935 mL	0.3870 mL	1.9348 mL
100 mM	0.0193 mL	0.0967 mL	0.1935 mL	0.9674 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc