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Dystonin Protein, Human, Recombinant (His)
(Synonyms: KIAA0728, Hemidesmosomal plaque protein, Dystonin, Dystonia musculorum protein, DT, DST, DMH, Bullous pemphigoid antigen 1 (BPA;Bullous pemphigoid antigen), BPAG1, BP240, BP230, 230/240 kDa bullous pemphigoid antigen, 230 kDa bullous pemphigoid antigen) Copy Product InfoSynonyms: KIAA0728, Hemidesmosomal plaque protein, Dystonin, Dystonia musculorum protein, DT, DST, DMH, Bullous pemphigoid antigen 1 (BPA;Bullous pemphigoid antigen), BPAG1, BP240, BP230, 230/240 kDa bullous pemphigoid antigen, 230 kDa bullous pemphigoid antigen
Catalog No. TMPH-01257 Copy Product Info
Purity: 96%
Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1.; plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.; required for bundling actin filaments around the nucleus.; regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $86 | - | In Stock | |
| 10 μg | $138 | - | In Stock | |
| 20 μg | $231 | - | In Stock | |
| 50 μg | $348 | - | In Stock | |
| 100 μg | $480 | - | In Stock | |
| 200 μg | $743 | 20 days | 20 days | |
| 500 μg | $1,330 | 20 days | 20 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:96%
Appearance:Lyophilized powder
Color:White
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Product Introduction
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| Description | Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1.; plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.; required for bundling actin filaments around the nucleus.; regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. |
| Species | Human |
| Expression System | P. pastoris (Yeast) |
| Tag | N-6xHis |
| Accession Number | Q03001 |
| Amino Acid | MHSSSYSYRSSDSVFSNTTSTRTSLDSNENLLLVHCGPTLINSCISFGSESFDGHRLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSG |
| Construction | 1-195 aa |
| Protein Purity | > 90% as determined by SDS-PAGE. https://cdn.targetmol.com/group3/M00/3F/D9/CgoaEGh2NMeEJwJPAAAAAKgHXTk907.jpg |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Tris-based buffer, 50% glycerol |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Synonyms | KIAA0728, Hemidesmosomal plaque protein, Dystonin, Dystonia musculorum protein, DT, DST, DMH, Bullous pemphigoid antigen 1 (BPA;Bullous pemphigoid antigen), BPAG1, BP240, BP230, 230/240 kDa bullous pemphigoid antigen, 230 kDa bullous pemphigoid antigen |
| Research Background |
| Molecular Weight | 23.7 kDa (predicted) |
| Storage | Store at low temperature Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Related Tags: Dystonin Protein, Human, Recombinant (His) chemical structure | Dystonin Protein, Human, Recombinant (His) molecular weight
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