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FR901464

Name: FR901464
Brand: TargetMol
SKU: T31866
Price: 328 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T31866Cas No. 146478-72-0

Alias WB 2663B, FR-901464, FR 901464

FR901464 (WB 2663B) is potent cytotoxic natural products that share an amine-containing tetrahydropyran ring.

FR901464

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Purity: 98.47%

Catalog No. T31866Alias WB 2663B, FR-901464, FR 901464Cas No. 146478-72-0

FR901464 (WB 2663B) is potent cytotoxic natural products that share an amine-containing tetrahydropyran ring.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$328	In Stock	In Stock
5 mg	$587	In Stock	In Stock
10 mg	$828	-	In Stock
25 mg	$1,470	-	In Stock
50 mg	$2,370	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.47%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	FR901464 (WB 2663B) is potent cytotoxic natural products that share an amine-containing tetrahydropyran ring.
In vitro	FR901464 (10-20 ng/ml; 6-24 hours) inhibited the growth of solid tumors, colon cancer, and methoxamine A fibrosarcoma in mice. FR901464 induced characteristic G1 and G2/M phase arrest in the cell cycle and internucleosomal degradation of genomic DNA in M-8 tumor cells by the same principle as SV40 promoter dependent cellular transcription. FR901464 (1-10 ng/ml) induced the transcription of some endogenous genes in M-8 cells, but did not inhibit the transcription of endogenous genes[1].
Synonyms	WB 2663B, FR-901464, FR 901464

Chemical Properties

Molecular Weight	507.62
Formula	C₂₇H₄₁NO₈
Cas No.	146478-72-0
Smiles	C[C@H](OC(C)=O)\C=C/C(=O)N[C@@H]1C[C@H](C)[C@H](C\C=C(/C)\C=C\[C@H]2O[C@](C)(O)C[C@@]3(CO3)[C@@H]2O)O[C@@H]1C
Relative Density.	1.21g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (177.3 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.5 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9700 mL	9.8499 mL	19.6998 mL	98.4989 mL
5 mM	0.3940 mL	1.9700 mL	3.9400 mL	19.6998 mL
10 mM	0.1970 mL	0.9850 mL	1.9700 mL	9.8499 mL
20 mM	0.0985 mL	0.4925 mL	0.9850 mL	4.9249 mL
50 mM	0.0394 mL	0.1970 mL	0.3940 mL	1.9700 mL
100 mM	0.0197 mL	0.0985 mL	0.1970 mL	0.9850 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc