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Cadonilimab (Synonyms: BTG502)

Catalog No. T76716 Copy Product Info
Purity: 95%
🥰Excellent
Cadonilimab (AK104) is a tetravalent PD-1/CTLA-4 bispecific humanised antibody that activates T cells by enhancing IL-2 and IFN-γ secretion while reducing pro-inflammatory cytokine secretion (e.g., IL-6, IL-8). It offers low toxicity and high affinity, making it suitable for metastatic cervical, gastric, hepatic, and pulmonary cancers, pancreatic cancer, and oesophageal squamous cell carcinoma.

Cadonilimab

Copy Product Info
🥰Excellent
Catalog No. T76716
Synonyms BTG502

Cadonilimab (AK104) is a tetravalent PD-1/CTLA-4 bispecific humanised antibody that activates T cells by enhancing IL-2 and IFN-γ secretion while reducing pro-inflammatory cytokine secretion (e.g., IL-6, IL-8). It offers low toxicity and high affinity, making it suitable for metastatic cervical, gastric, hepatic, and pulmonary cancers, pancreatic cancer, and oesophageal squamous cell carcinoma.

Cadonilimab
Cas No. 2394841-59-7
Pack SizePriceUSA StockGlobal StockQuantity
1 mg$373-In Stock
5 mg$1,200-In Stock
10 mg$1,9902-4 weeks2-4 weeks
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:95%
Appearance:Liquid
Color:Transparent
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Product Introduction

Bioactivity
Description
Cadonilimab (AK104) is a tetravalent PD-1/CTLA-4 bispecific humanised antibody that activates T cells by enhancing IL-2 and IFN-γ secretion while reducing pro-inflammatory cytokine secretion (e.g., IL-6, IL-8). It offers low toxicity and high affinity, making it suitable for metastatic cervical, gastric, hepatic, and pulmonary cancers, pancreatic cancer, and oesophageal squamous cell carcinoma.
In vivo
Methods: The NCG mouse subcutaneous xenograft model (MGC803 cell line) was employed, with cadonilimab administered via intraperitoneal injection. The dosing regimen was as follows: the first three doses at 1 mg/kg (initiated on day 4 post-grouping, twice weekly for three consecutive weeks), followed by six doses at 5 mg/kg (twice weekly for six consecutive weeks).
Result: Cadonilimab demonstrated significant anti-tumor efficacy when combined with chemotherapy, but exhibited limited effectiveness when used alone.[1]
SynonymsBTG502
Reactivity
Human
Application
Functional assay
Antibody Type
Monoclonal
FormulationSupplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
Endotoxin<1.0 EU/mg
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Gene ID
Uniprot ID
TargetCTLA4 & PDCD1
Chemical Properties
Molecular Weight198.64 kDa
Cas No.2394841-59-7
Antibody Information
IsotypeHuman IgG1 kappa
Recommended Isotype Control
Storage & Solubility Information
Storagestore at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature.

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