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Aclacinomycin A hydrochloride

Name: Aclacinomycin A hydrochloride
Brand: TargetMol
SKU: T10238
Price: 453 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10238Cas No. 75443-99-1

Alias Aclarubicin hydrochloride

Aclacinomycin A hydrochloride (Aclarubicin HCl) is an anthracycline antibiotic and inhibitor of topoisomerase I/II, interfering with DNA transcription and replication, inhibiting tumour invasion and angiogenesis, generating reactive oxygen species (ROS), and inhibiting the catalytic centre of the 20S proteasome. It is indicated for the treatment of relapsed leukaemia and advanced malignant lymphoma.

Aclacinomycin A hydrochloride

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Catalog No. T10238Alias Aclarubicin hydrochlorideCas No. 75443-99-1

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$453	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:Orange

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Product Introduction

Bioactivity

Description	Aclacinomycin A hydrochloride (Aclarubicin HCl) is an anthracycline antibiotic and inhibitor of topoisomerase I/II, interfering with DNA transcription and replication, inhibiting tumour invasion and angiogenesis, generating reactive oxygen species (ROS), and inhibiting the catalytic centre of the 20S proteasome. It is indicated for the treatment of relapsed leukaemia and advanced malignant lymphoma.
In vitro	Method: A cell viability assay was performed using V79 and irs-2 cell lines. Cells were treated with varying concentrations of Aclacinomycin A hydrochloride at 0, 0.006, 0.12, 1.2, and 2.4 μM for 3 hours. The effect on the catalytic activity of topoisomerase II (topo II) was evaluated. Result: Aclacinomycin A hydrochloride significantly inhibited topo II catalytic activity in a dose-dependent manner. Compared to the untreated group, all treated groups showed a statistically significant decrease in topo II activity, indicating that the drug effectively interferes with topo II function and subsequently affects cell viability. [2]
In vivo	Method: P-388 leukemia cells were transplanted into DBA/2 and CDF1 (BALB/c × DBA/2) mice. Starting 3 hours after transplantation, mice received daily intraperitoneal injections of Aclacinomycin A hydrochloride for 10 consecutive days at doses of 0.75, 1.5, 3, and 6 mg/kg. Result: Aclacinomycin A hydrochloride significantly inhibited tumor growth in a dose-dependent manner.[3]
Animal Research	Animal Model: DBA/2, CDF1 (BALB/c×DBA/2) mice with Leukemia P-388. Dosage: 0.75 mg/kg, 1.5 mg/kg, 3 mg/kg, 6 mg/kg. Administration: Intraperitoneal administration daily for 10 days starting 3 hr after transplantation. Result: Inhibited tumor growth [4].
Synonyms	Aclarubicin hydrochloride

Chemical Properties

Molecular Weight	848.33
Formula	C₄₂H₅₄ClNO₁₅
Cas No.	75443-99-1
Smiles	C(OC)(=O)[C@@H]1C2=C([C@@H](O[C@H]3C[C@H](N(C)C)[C@H](O[C@H]4C[C@H](O)[C@H](O[C@@H]5O[C@@H](C)C(=O)CC5)[C@H](C)O4)[C@H](C)O3)C[C@@]1(CC)O)C(O)=C6C(=C2)C(=O)C=7C(C6=O)=C(O)C=CC7.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120 mg/mL (141.45 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (4.72 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1788 mL	5.8939 mL	11.7879 mL	58.9393 mL
5 mM	0.2358 mL	1.1788 mL	2.3576 mL	11.7879 mL
10 mM	0.1179 mL	0.5894 mL	1.1788 mL	5.8939 mL
20 mM	0.0589 mL	0.2947 mL	0.5894 mL	2.9470 mL
50 mM	0.0236 mL	0.1179 mL	0.2358 mL	1.1788 mL
100 mM	0.0118 mL	0.0589 mL	0.1179 mL	0.5894 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc