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SGC-CK2-1

Name: SGC-CK2-1
Brand: TargetMol
SKU: T40131
Price: 49 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40131Cas No. 2470424-39-4

SGC-CK2-1 is a highly specific inhibitor of CK2, a inducer of insulin production and secretion in pancreatic β-cells, and can be used in the study of neurodegenerative diseases.

SGC-CK2-1

🥰Excellent

Purity: 99.41%

Catalog No. T40131Cas No. 2470424-39-4

SGC-CK2-1 is a highly specific inhibitor of CK2, a inducer of insulin production and secretion in pancreatic β-cells, and can be used in the study of neurodegenerative diseases.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$49	-	In Stock
5 mg	$85	-	In Stock
1 mL x 10 mM (in DMSO)	$299	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.41%

Resource Download

COA HNMR HPLC MS

Product Introduction

Bioactivity

Description	SGC-CK2-1 is a highly specific inhibitor of CK2, a inducer of insulin production and secretion in pancreatic β-cells, and can be used in the study of neurodegenerative diseases.
Targets&IC50	CSNK2A2:2.3 nM, CSNK2A1:4.2 nM, CK2α:36 nM (IC50), DYRK2:3.7 μM, CK2α:16 nM (IC50)
In vitro	SGC-CK2-1 is a selective inhibitor with IC50 values of 2.3 nM and 4.2 nM for CSNK2A2 and CSNK2A1, respectively, and an IC50 value of 3.7 μM for DYRK2[1].

Chemical Properties

Molecular Weight	375.43
Formula	C₂₀H₂₁N₇O
Cas No.	2470424-39-4
Smiles	CCC(=O)Nc1cc(Nc2cc(NC3CC3)n3ncc(C#N)c3n2)ccc1C

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (213.09 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (8.79 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6636 mL	13.3181 mL	26.6361 mL	133.1806 mL
5 mM	0.5327 mL	2.6636 mL	5.3272 mL	26.6361 mL
10 mM	0.2664 mL	1.3318 mL	2.6636 mL	13.3181 mL
20 mM	0.1332 mL	0.6659 mL	1.3318 mL	6.6590 mL
50 mM	0.0533 mL	0.2664 mL	0.5327 mL	2.6636 mL
100 mM	0.0266 mL	0.1332 mL	0.2664 mL	1.3318 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc