Contact UsQuotation
Shopping Cart
Remove All
  • TargetMol
    Your shopping cart is currently empty
Proceed to checkoutContinue shopping
TOPBioactivityChemical infoStorage&SolubilityCalculator

Bis-T-23

Copy Product Info
🥰Excellent
Catalog No. T30479Cas No. 171674-76-3
Alias Bis-T 23, Bis T-23, AG1717

Bis-T-23 is a promoter of actin-dependent dynamin oligomerization, an HIV-I integrase inhibitor, and a Telstar derivative. Bis-T-23 promotes actin-dependent dynamin oligomerization. Bis-T-23 can be used in studies of HIV and chronic kidney disease (CKD).

Bis-T-23

Bis-T-23

Copy Product Info
🥰Excellent
Purity: 98.87%
Catalog No. T30479Alias Bis-T 23, Bis T-23, AG1717Cas No. 171674-76-3
Bis-T-23 is a promoter of actin-dependent dynamin oligomerization, an HIV-I integrase inhibitor, and a Telstar derivative. Bis-T-23 promotes actin-dependent dynamin oligomerization. Bis-T-23 can be used in studies of HIV and chronic kidney disease (CKD).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$289In StockIn Stock
5 mg$685In StockIn Stock
10 mg$936In StockIn Stock
25 mg$1,450In StockIn Stock
50 mg$1,950In StockIn Stock
100 mg$2,500In StockIn Stock
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
TargetMol
View More

Batch Information

Select Batch
Purity:98.87%
Appearance:Solid
Color:Yellow
Contact us for more batch information

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity
Description
Bis-T-23 is a promoter of actin-dependent dynamin oligomerization, an HIV-I integrase inhibitor, and a Telstar derivative. Bis-T-23 promotes actin-dependent dynamin oligomerization. Bis-T-23 can be used in studies of HIV and chronic kidney disease (CKD).
In vitro
Bis-T-23 (AG1717) (0.18 μM) inhibits HIV-1 integrase and, at a concentration of 2 μM, AG1717 also inhibits the binding of integrase to substrate DNA.[5]
In vivo
Bis-T-23 (1 ng) targets actin-dependent kinesin oligomerization in podocytes to promote normal GFB function. Bis-T-23 (i.p.; 20, 40 mg/kg) improves proteinuria by altering actin kinetics and reduces thylakoid matrix expansion in various genetic and chronic glomerular disease models in rodents.[6]
SynonymsBis-T 23, Bis T-23, AG1717
Chemical Properties
Molecular Weight480.43
FormulaC23H20N4O8
Cas No.171674-76-3
SmilesC(=C(/C(NCCCNC(/C(=C/C1=CC(O)=C(O)C(O)=C1)/C#N)=O)=O)\C#N)\C2=CC(O)=C(O)C(O)=C2
Relative Density.1.582 g/cm3 (Predicted)
Storage & Solubility Information
StorageIn solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: Insoluble
DMSO: 12.01 mg/mL (25 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0815 mL10.4073 mL20.8147 mL104.0734 mL
5 mM0.4163 mL2.0815 mL4.1629 mL20.8147 mL
10 mM0.2081 mL1.0407 mL2.0815 mL10.4073 mL
20 mM0.1041 mL0.5204 mL1.0407 mL5.2037 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

HIVProteaseHIV ProteaseHIV integraseBis-T-23AG-1717AG 1717
Related Tags: buy Bis-T-23 | purchase Bis-T-23 | Bis-T-23 cost | order Bis-T-23 | Bis-T-23 chemical structure | Bis-T-23 in vivo | Bis-T-23 in vitro | Bis-T-23 formula | Bis-T-23 molecular weight
TargetMol | Logo

Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.