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L-Alanosine
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Catalog No. T15691Cas No. 5854-93-3
Alias SDX-102, SDX102, NSC153353, NSC 153353
L-Alanosine, an antibiotic isolated from the fermentation product of Streptomyces alanosinicus, inhibits tumor cell proliferation by blocking the adenylosuccinate synthetic pathway through the inhibition of adenylosuccinate synthetase and Methylthioadenosine phosphorylase.
L-Alanosine
😃Good
Catalog No. T15691Alias SDX-102, SDX102, NSC153353, NSC 153353Cas No. 5854-93-3
L-Alanosine, an antibiotic isolated from the fermentation product of Streptomyces alanosinicus, inhibits tumor cell proliferation by blocking the adenylosuccinate synthetic pathway through the inhibition of adenylosuccinate synthetase and Methylthioadenosine phosphorylase.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $123 | In Stock | |
| 5 mg | $363 | 7-10 days | |
| 10 mg | $619 | 7-10 days | |
| 25 mg | $965 | 7-10 days | |
| 50 mg | $1,280 | 7-10 days | |
| 100 mg | $1,750 | 7-10 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | L-Alanosine, an antibiotic isolated from the fermentation product of Streptomyces alanosinicus, inhibits tumor cell proliferation by blocking the adenylosuccinate synthetic pathway through the inhibition of adenylosuccinate synthetase and Methylthioadenosine phosphorylase. |
| In vitro | Methods: GBM cells were treated with L-Alanosine (0.25 μM and 0.5 μM for two weeks) to evaluate the effect of pre-exposure to ALA on OCR. Results: Pre-exposure to L-Alanosine resulted in a significant attenuation of maximal OCR (and abolished mitochondrial spare respiratory capacity.[4] |
| In vivo | Methods: L-Alanosine (150 mg/kg, i.p., three times per week) was administered to athymic nude mice transplanted with luciferase-expressing MTAP-deficient GBM cells that were injected with TMZ. In vivo drug responses were monitored by weekly bioluminescence imaging of the mice and analyzed using Living Image software. Results: Monotherapy with either TMZ or L-Alanosine alone was moderately effective in vivo, inhibiting tumor growth compared to vehicle-treated groups. Importantly, tumors in the combination treatment group remained stable after cessation of treatment compared to the monotherapy groups. [1] |
| Alias | SDX-102, SDX102, NSC153353, NSC 153353 |
| Molecular Weight | 149.11 |
| Formula | C3H7N3O4 |
| Cas No. | 5854-93-3 |
| Smiles | C([C@@H](C(O)=O)N)N(N=O)O |
| Relative Density. | 1.81g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | H2O: 10 mg/mL (67.06 mM), adjust pH to 8 with NaOH. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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