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L-Alanosine

Name: L-Alanosine
Brand: TargetMol
SKU: T15691
Price: 123 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15691Cas No. 5854-93-3

Alias SDX-102, SDX102, NSC153353, NSC 153353

L-Alanosine, an antibiotic isolated from the fermentation product of Streptomyces alanosinicus, inhibits tumor cell proliferation by blocking the adenylosuccinate synthetic pathway through the inhibition of adenylosuccinate synthetase and Methylthioadenosine phosphorylase.

L-Alanosine

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Catalog No. T15691Alias SDX-102, SDX102, NSC153353, NSC 153353Cas No. 5854-93-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$123	-	In Stock
5 mg	$363	7-10 days	7-10 days
10 mg	$619	7-10 days	7-10 days
25 mg	$965	7-10 days	7-10 days
50 mg	$1,280	7-10 days	7-10 days
100 mg	$1,750	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	L-Alanosine, an antibiotic isolated from the fermentation product of Streptomyces alanosinicus, inhibits tumor cell proliferation by blocking the adenylosuccinate synthetic pathway through the inhibition of adenylosuccinate synthetase and Methylthioadenosine phosphorylase.
In vitro	Methods: GBM cells were treated with L-Alanosine (0.25 μM and 0.5 μM for two weeks) to evaluate the effect of pre-exposure to ALA on OCR. Results: Pre-exposure to L-Alanosine resulted in a significant attenuation of maximal OCR (and abolished mitochondrial spare respiratory capacity.[4]
In vivo	Methods: L-Alanosine (150 mg/kg, i.p., three times per week) was administered to athymic nude mice transplanted with luciferase-expressing MTAP-deficient GBM cells that were injected with TMZ. In vivo drug responses were monitored by weekly bioluminescence imaging of the mice and analyzed using Living Image software. Results: Monotherapy with either TMZ or L-Alanosine alone was moderately effective in vivo, inhibiting tumor growth compared to vehicle-treated groups. Importantly, tumors in the combination treatment group remained stable after cessation of treatment compared to the monotherapy groups. [1]
Synonyms	SDX-102, SDX102, NSC153353, NSC 153353

Chemical Properties

Molecular Weight	149.11
Formula	C₃H₇N₃O₄
Cas No.	5854-93-3
Smiles	C([C@@H](C(O)=O)N)N(N=O)O
Relative Density.	1.81g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 10 mg/mL (67.06 mM), when pH is adjusted to 8 with NaOH. Sonication is recommmended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	6.7065 mL	33.5323 mL	67.0646 mL	335.3229 mL
5 mM	1.3413 mL	6.7065 mL	13.4129 mL	67.0646 mL
10 mM	0.6706 mL	3.3532 mL	6.7065 mL	33.5323 mL
20 mM	0.3353 mL	1.6766 mL	3.3532 mL	16.7661 mL
50 mM	0.1341 mL	0.6706 mL	1.3413 mL	6.7065 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc