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PACMA 31

Name: PACMA 31
Brand: TargetMol
SKU: T41277
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T41277Cas No. 1401089-31-3

PACMA 31 is an irreversible and covalent inhibitor of protein disulfide isomerase (PDI) with an IC50 of 10 μM. PACMA 31 significantly suppresses ovarian tumor growth and exhibits tumor targeting ability.

PACMA 31

🥰Excellent

Purity: 99.92%

Catalog No. T41277Cas No. 1401089-31-3

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$32	In Stock	In Stock
5 mg	$50	In Stock	In Stock
10 mg	$89	In Stock	In Stock
25 mg	$181	In Stock	In Stock
50 mg	$305	In Stock	In Stock
100 mg	$508	-	In Stock
200 mg	$723	-	In Stock
1 mL x 10 mM (in DMSO)	$55	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.92%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	PACMA 31 is an irreversible and covalent inhibitor of protein disulfide isomerase (PDI) with an IC50 of 10 μM. PACMA 31 significantly suppresses ovarian tumor growth and exhibits tumor targeting ability.
In vitro	In OVCAR-8 cells, PACMA 31 (0-10 μM) potently inhibits colony formation in a dose-dependent manner[1].
In vivo	In human ovarian cancer mouse xenografts, PACMA 31 (20-200 mg/kg) i.p. or per os administration of significantly inhibited tumor growth by 85% and 65% at day 62, respectively[1].

Chemical Properties

Molecular Weight	430.47
Formula	C₂₁H₂₂N₂O₆S
Cas No.	1401089-31-3
Smiles	CCOC(=O)CNC(=O)C(N(C(=O)C#C)c1ccc(OC)cc1OC)c1cccs1
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (232.3 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (9.29 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3230 mL	11.6152 mL	23.2304 mL	116.1521 mL
5 mM	0.4646 mL	2.3230 mL	4.6461 mL	23.2304 mL
10 mM	0.2323 mL	1.1615 mL	2.3230 mL	11.6152 mL
20 mM	0.1162 mL	0.5808 mL	1.1615 mL	5.8076 mL
50 mM	0.0465 mL	0.2323 mL	0.4646 mL	2.3230 mL
100 mM	0.0232 mL	0.1162 mL	0.2323 mL	1.1615 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc