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Dilmapimod

Name: Dilmapimod
Brand: TargetMol
SKU: T12850
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T12850Cas No. 444606-18-2

Alias SB-681323, GW 681323

Dilmapimod (SB-681323) is a potent inhibitor of p38 MAPK, potentially suppressing inflammation in chronic obstructive pulmonary disease.

Dilmapimod

🥰Excellent

Purity: 97.53%

Catalog No. T12850Alias SB-681323, GW 681323Cas No. 444606-18-2

Dilmapimod (SB-681323) is a potent inhibitor of p38 MAPK, potentially suppressing inflammation in chronic obstructive pulmonary disease.

Pack Size	Price	Availability
5 mg	$39	In Stock
10 mg	$64	In Stock
25 mg	$122	In Stock
50 mg	$198	In Stock
100 mg	$369	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock

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Batch Information

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Purity:97.53%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Dilmapimod (SB-681323) is a potent inhibitor of p38 MAPK, potentially suppressing inflammation in chronic obstructive pulmonary disease.
In vitro	p38 MAPK signaling potently inhibited by Dilmapimod, measured by inhibition of sorbitol-induced pHSP27 expression.
Synonyms	SB-681323, GW 681323

Chemical Properties

Molecular Weight	456.42
Formula	C₂₃H₁₉F₃N₄O₃
Cas No.	444606-18-2
Smiles	Cc1cc(F)ccc1-c1nc(NC(CO)CO)nc2n(-c3c(F)cccc3F)c(=O)ccc12
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (273.87 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1910 mL	10.9548 mL	21.9096 mL	109.5482 mL
5 mM	0.4382 mL	2.1910 mL	4.3819 mL	21.9096 mL
10 mM	0.2191 mL	1.0955 mL	2.1910 mL	10.9548 mL
20 mM	0.1095 mL	0.5477 mL	1.0955 mL	5.4774 mL
50 mM	0.0438 mL	0.2191 mL	0.4382 mL	2.1910 mL
100 mM	0.0219 mL	0.1095 mL	0.2191 mL	1.0955 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc