Shopping Cart

Your shopping cart is currently empty

4-Hydroxybenzoic acid

Name: 4-Hydroxybenzoic acid
Brand: TargetMol
SKU: T2989
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T2989Cas No. 99-96-7

Alias p-hydroxybenzoic acid, PHBA, para-Hydroxybenzoic acid, 4-hydroxybenzoate

4-Hydroxybenzoic acid (4-hydroxybenzoate) is a monohydroxybenzoic acid, a phenolic derivative of benzoic acid. It is a white crystalline solid that is slightly soluble in water and chloroform but more soluble in polar organic solvents such as alcohols. It could inhibit most gram-positive and some gram-negative bacteria, with an IC50 of 160 μg/mL.

4-Hydroxybenzoic acid

Copy Product Info

😃Good

Purity: 99.86%

Catalog No. T2989Alias p-hydroxybenzoic acid, PHBA, para-Hydroxybenzoic acid, 4-hydroxybenzoateCas No. 99-96-7

Pack Size	Price	USA Warehouse	Global Warehouse
5 g	$35	-	In Stock
10 g	$44	-	In Stock
25 g	$58	-	In Stock
50 g	$71	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.86%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

4-Hydroxybenzoic acid AI Summary

4-Hydroxybenzoic acid is a multi-faceted agent characterized by various physicochemical properties and bioactivities. It demonstrates a Hammett constant of -0.37 and a LogP value of 1.57, suggesting moderate lipophilicity and electronic effects. It exhibits long half-life (over 50 hours) for methyl ester hydrolysis in human plasma and a short half-life (0.03 hours) for N,N-diethylglycolamide ester hydrolysis under physiological conditions. Its toxicity profile indicates a pLD50 in rats of 9.21, moderate cytotoxicity in certain cell lines (e.g., HeLa and mouse Colon 26-L5 cells), and a Log 1/LD50 value of 1.29. The compound displays inhibitory effects on various enzymes, including human thiopurine methyltransferase (IC50: 1737800.83 nM), carbonic anhydrase isoforms with Ki values ranging from 870 nM to 7790 nM, and tyrosinase (IC50: 9350 nM). It also acts as an inhibitor of several pathogens and substrates, including antitubercular (MIC: 362000 nM), antifungal against Saccharomyces cerevisiae (MIC: 1600.0 ug/mL), and antimicrobial against Ralstonia solanacearum. 4-Hydroxybenzoic acid shows antioxidant activity through DPPH radical scavenging (IC50: 183.7 ug/mL) and exhibits moderate cytotoxicity against a range of cell lines. Its inhibition potency includes activities against H1N9 Influenza neuraminidase, dihydroorotate dehydrogenase from Lactococcus lactis (92% inhibition at 1 µM), and human carbonic anhydrase (multiple isozymes). Additionally, the compound exerts modest anti-inflammatory effects by reducing LPS-induced nitric oxide production in RAW264.7 cells (IC50: 72800.0 nM) and has PPARgamma agonist activity demonstrated in human HepG2 cells with fold changes up to 1.35. Importantly, it has a notable effect on the inhibition of amyloid beta fibril formation, suggestive of potential neuroprotective attributes. The diverse range of activities and properties make 4-Hydroxybenzoic acid a candidate of significant interest for pharmaceutical and biochemical applications, reflecting its multipotential bioactive profile across various assays and biological models..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	4-Hydroxybenzoic acid (4-hydroxybenzoate) is a monohydroxybenzoic acid, a phenolic derivative of benzoic acid. It is a white crystalline solid that is slightly soluble in water and chloroform but more soluble in polar organic solvents such as alcohols. It could inhibit most gram-positive and some gram-negative bacteria, with an IC50 of 160 μg/mL.
Targets&IC50	Antibacterial:160 μg/mL (IC50)
Synonyms	p-hydroxybenzoic acid, PHBA, para-Hydroxybenzoic acid, 4-hydroxybenzoate

Chemical Properties

Molecular Weight	138.12
Formula	C₇H₆O₃
Cas No.	99-96-7
Smiles	OC(=O)C1=CC=C(O)C=C1
Relative Density.	> 1.34 - < 1.46. Temperature:20 °C.

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 245 mg/mL (1773.82 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (36.2 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	7.2401 mL	36.2004 mL	72.4008 mL	362.0041 mL
5 mM	1.4480 mL	7.2401 mL	14.4802 mL	72.4008 mL
10 mM	0.7240 mL	3.6200 mL	7.2401 mL	36.2004 mL
20 mM	0.3620 mL	1.8100 mL	3.6200 mL	18.1002 mL
50 mM	0.1448 mL	0.7240 mL	1.4480 mL	7.2401 mL
100 mM	0.0724 mL	0.3620 mL	0.7240 mL	3.6200 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc