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Latanoprost acid

Name: Latanoprost acid
Brand: TargetMol
SKU: T15718
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15718Cas No. 41639-83-2

Latanoprost acid is a selective agonist of prostanoid receptors and inhibits RANKL-induced osteoclastogenesis and function through the inhibition of c-fos/NFATc1 pathway. Latanoprost acid can be used in studies about lowering pressure inside the eyes.

Latanoprost acid

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Purity: 97.96%

Catalog No. T15718Cas No. 41639-83-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$52	-	In Stock
5 mg	$148	-	In Stock
10 mg	$238	-	In Stock
25 mg	$477	-	In Stock
50 mg	$708	-	In Stock
100 mg	$972	-	In Stock
200 mg	$1,290	-	In Stock
1 mL x 10 mM (in DMSO)	$163	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.96%

Appearance:Oil

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Latanoprost acid is a selective agonist of prostanoid receptors and inhibits RANKL-induced osteoclastogenesis and function through the inhibition of c-fos/NFATc1 pathway. Latanoprost acid can be used in studies about lowering pressure inside the eyes.
In vitro	Latanoprost acid (10, 20 μM) reduces the protein expressions of c-fos and NFATc1 thus inhibiting the mature osteoclast formation in BMMs. Latanoprost acid (10μM) and RANKL(50ng/ml) significantly inhibit ERK, p38, AKT and JNK[1].
In vivo	Latanoprost acid (i.p.; 20 mg/kg; once daily for 7 days) effectively prevents LPS-induced bone destruction [1].

Chemical Properties

Molecular Weight	390.51
Formula	C₂₃H₃₄O₅
Cas No.	41639-83-2
Smiles	O[C@H](CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O)CCc1ccccc1
Relative Density.	1.159 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 27.5 mg/mL (70.42 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.12 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5608 mL	12.8038 mL	25.6075 mL	128.0377 mL
5 mM	0.5122 mL	2.5608 mL	5.1215 mL	25.6075 mL
10 mM	0.2561 mL	1.2804 mL	2.5608 mL	12.8038 mL
20 mM	0.1280 mL	0.6402 mL	1.2804 mL	6.4019 mL
50 mM	0.0512 mL	0.2561 mL	0.5122 mL	2.5608 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc