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Anti-VEGFR2/KDR Antibody (7C203)
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Catalog No. TMAY-03511
Alias VEGFR2, VEGFR, kinase insert domain receptor, Flk-1, FLK1, CD309
Anti-VEGFR2/KDR Antibody (7C203) is a Rabbit antibody targeting VEGFR2/KDR. Anti-VEGFR2/KDR Antibody (7C203) can be used in ELISA.
Anti-VEGFR2/KDR Antibody (7C203)
Anti-VEGFR2/KDR Antibody (7C203)
😃Good
Catalog No. TMAY-03511Alias VEGFR2, VEGFR, kinase insert domain receptor, Flk-1, FLK1, CD309
Anti-VEGFR2/KDR Antibody (7C203) is a Rabbit antibody targeting VEGFR2/KDR. Anti-VEGFR2/KDR Antibody (7C203) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $269 | 7-10 days |
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Product Introduction
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Antigen Details
Chemical Properties
| Description | Anti-VEGFR2/KDR Antibody (7C203) is a Rabbit antibody targeting VEGFR2/KDR. Anti-VEGFR2/KDR Antibody (7C203) can be used in ELISA. |
| Alias | VEGFR2, VEGFR, kinase insert domain receptor, Flk-1, FLK1, CD309 |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 7C203 |
| Reactivity | Mouse |
| Application | ELISA |
| Recommended Dose | ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse VEGFR2 / Flk-1 / CD309 / KDR (rM VEGFR2 / Flk-1 / CD309 / KDR; TMPY-02736; P35918-1; Met1-Glu762). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be the primary signal transducer for angiogenesis and the development of pathological conditions such as cancer and diabetic retinopathy. It has been shown that VEGFR2 is expressed mainly in the endothelial cells, and the expression is upregulated in the tumor vasculature. Thus the inhibition of VEGFR2 activity and its downstream signaling are important targets for the treatment of diseases involving angiogenesis. VEGFR2 transduces the major signals for angiogenesis via its strong tyrosine kinase activity. However, unlike other representative tyrosine kinase receptors, VEGFR2 does not use the Ras pathway as major downstream signaling but rather uses the phospholipase C-protein kinase C pathway to signal mitogen-activated protein (MAP)-kinase activation and DNA synthesis. VEGFR2 is a direct and major signal transducer for pathological angiogenesis, including cancer and diabetic retinopathy, in cooperation with many other signaling partners; thus, VEGFR2 and its downstream signaling appear to be critical targets for the suppression of these diseases. VEGF and VEGFR2-mediated survival signaling are critical to endothelial cell survival, maintenance of the vasculature and alveolar structure, and regeneration of lung tissue. Reduced VEGF and VEGFR2 expression in emphysematous lungs has been linked to increased endothelial cell death and vascular regression.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Mouse VEGFR2 / Flk-1 / CD309 / KDR protein (TMPY-02736) |
| Antigen Species | Mouse |
| Biology Area | Cancer Drug Targets, Hemangioblast Markers, Receptor Tyrosine Kinases (RTKs) |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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