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TH1338

Name: TH1338
Brand: TargetMol
SKU: T28959
Price: 81 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28959Cas No. 1258494-60-8

Alias TH-1318

TH1338 is an orally active derivative of camptothecin with potential anti-cancer activity. TH1338 exhibits significant blood-brain barrier penetration and cytotoxicity, useful for cancer research.

TH1338

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Purity: 98.77%

Catalog No. T28959Alias TH-1318Cas No. 1258494-60-8

TH1338 is an orally active derivative of camptothecin with potential anti-cancer activity. TH1338 exhibits significant blood-brain barrier penetration and cytotoxicity, useful for cancer research.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$81	In Stock	In Stock
5 mg	$197	In Stock	In Stock
10 mg	$338	-	In Stock
25 mg	$668	-	In Stock
50 mg	$935	-	In Stock
1 mL x 10 mM (in DMSO)	$217	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.77%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	TH1338 is an orally active derivative of camptothecin with potential anti-cancer activity. TH1338 exhibits significant blood-brain barrier penetration and cytotoxicity, useful for cancer research.
In vitro	The IC50 values of TH1338 against H460, PC-3 HT29, SK-MEL-2 and A375 were 7 nM, 24 nM, 300 nM, 130 nM and 7 nM, respectively. [1]
In vivo	TH1338 (50 mg/kg orally) showed significant brain permeability. TH1338 (40 mg/kg, orally) showed 84% tumor growth inhibition in H460 xenograft models. [1]
Synonyms	TH-1318

Chemical Properties

Molecular Weight	391.42
Formula	C₂₂H₂₁N₃O₄
Cas No.	1258494-60-8
Smiles	NC1=C2C=3C(CN2C(=O)C4=C1[C@](CC)(O)C(=O)OC4)=C(CC)C=5C(N3)=CC=CC5
Relative Density.	1.47 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 8 mg/mL (20.44 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 0.5 mg/mL (1.28 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5548 mL	12.7740 mL	25.5480 mL	127.7400 mL
5 mM	0.5110 mL	2.5548 mL	5.1096 mL	25.5480 mL
10 mM	0.2555 mL	1.2774 mL	2.5548 mL	12.7740 mL
20 mM	0.1277 mL	0.6387 mL	1.2774 mL	6.3870 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc