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TH1338

Name: TH1338
Brand: TargetMol
SKU: T28959
Price: 81 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28959Cas No. 1258494-60-8

Alias TH-1318

TH1338 is an orally active derivative of camptothecin with potential anti-cancer activity. TH1338 exhibits significant blood-brain barrier penetration and cytotoxicity, useful for cancer research.

TH1338

🥰Excellent

Purity: 98.77%

Catalog No. T28959Alias TH-1318Cas No. 1258494-60-8

TH1338 is an orally active derivative of camptothecin with potential anti-cancer activity. TH1338 exhibits significant blood-brain barrier penetration and cytotoxicity, useful for cancer research.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$81	In Stock	In Stock
5 mg	$197	In Stock	In Stock
10 mg	$338	-	In Stock
25 mg	$668	-	In Stock
50 mg	$935	-	In Stock
1 mL x 10 mM (in DMSO)	$217	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.77%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	TH1338 is an orally active derivative of camptothecin with potential anti-cancer activity. TH1338 exhibits significant blood-brain barrier penetration and cytotoxicity, useful for cancer research.
In vitro	The IC50 values of TH1338 against H460, PC-3 HT29, SK-MEL-2 and A375 were 7 nM, 24 nM, 300 nM, 130 nM and 7 nM, respectively. [1]
In vivo	TH1338 (50 mg/kg orally) showed significant brain permeability. TH1338 (40 mg/kg, orally) showed 84% tumor growth inhibition in H460 xenograft models. [1]
Synonyms	TH-1318

Chemical Properties

Molecular Weight	391.42
Formula	C₂₂H₂₁N₃O₄
Cas No.	1258494-60-8
Smiles	NC1=C2C=3C(CN2C(=O)C4=C1[C@](CC)(O)C(=O)OC4)=C(CC)C=5C(N3)=CC=CC5
Relative Density.	1.47 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 8 mg/mL (20.44 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 0.5 mg/mL (1.28 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5548 mL	12.7740 mL	25.5480 mL	127.7400 mL
5 mM	0.5110 mL	2.5548 mL	5.1096 mL	25.5480 mL
10 mM	0.2555 mL	1.2774 mL	2.5548 mL	12.7740 mL
20 mM	0.1277 mL	0.6387 mL	1.2774 mL	6.3870 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc