UM-242 is a STING inhibitor with an EC50 of 1.70 μM in THP1-Dual cells expressing wild-type STING. It disrupts STING oligomerization and inhibits diABZI-induced phosphorylation of TBK1 and IRF3, thereby suppressing the transcription of IFNβ and IL6 and reducing IFNβ secretion. UM-242 can be utilized in research on STING-dependent inflammatory and neurological diseases.

UM-242, when used at concentrations of 0.2-5 μM and pre-treated for 1 hour, exhibits potent inhibitory activity on diABZI-induced IFNβ and IL6 gene transcription in iBMDMs. At a concentration of 2.5 μM with the same pre-treatment duration, UM-242 demonstrates strong activity in blocking STING-dependent IFNβ secretion in primary human CD14+ monocytes. Additionally, UM-242, at a 5 μM concentration with a 1-hour pre-treatment, strongly inhibits diABZI-induced TBK1 and IRF3 phosphorylation and effectively suppresses STING oligomerization in WT BMDMs, significantly blocking downstream STING signaling.