Human IL-18BP, hFc Tag captured on CM5 Chip via Protein A can bind Human IL-37, No Tag with an affinity constant of 0.12 μM as determined in SPR assay (Biacore T200).

IL-37 Protein, Human, Recombinant V2 is expressed in E. coli. The accession number is Q9NZH6-2.

Human

E. coli

interleukin 37,IL-37,IL37,IL-1RP1,IL1RP1,IL-1H4,IL1H4,IL-1H,IL-1F7,IL1F7,FIL1Z,FIL1(ζ),FIL1(ZETA),FIL1

Lys27-Asp192

> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC

Reconstitute the lyophilized protein in sterile deionized water. The product concentration should not be less than 100 μg/mL. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

IL-37 is a unique member of the IL-1 family of cytokines, which functions as a natural suppressor of inflammatory and immune responses. Immune and non-immune cells produce IL-37 precursor following pro-inflammatory stimuli. Following activating cleavage by caspase-1, mature IL-37 translocates to the nucleus, where it suppresses transcription of pro-inflammatory genes.