IL-37 Protein, Human, Recombinant V2

Name: IL-37 Protein, Human, Recombinant V2
Brand: TargetMol
SKU: TMPY-02597U
Rating: 4.5 (1 reviews)

(Synonyms: interleukin 37, IL-37, IL37, IL-1RP1, IL1RP1, IL-1H4, IL1H4, IL-1H, IL-1F7, IL1F7, FIL1Z, FIL1(ζ), FIL1(ZETA), FIL1) Copy Product Info

Synonyms: interleukin 37, IL-37, IL37, IL-1RP1, IL1RP1, IL-1H4, IL1H4, IL-1H, IL-1F7, IL1F7, FIL1Z, FIL1(ζ), FIL1(ZETA), FIL1

Catalog No. TMPY-02597U Copy Product Info

IL-37 Protein, Human, Recombinant V2 is expressed in E. coli. The accession number is Q9NZH6-2.

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Pack Size	Price	USA Stock	Global Stock
5 µg	$80	7-10 days	7-10 days
10 µg	$129	7-10 days	7-10 days
20 µg	$212	7-10 days	7-10 days
50 µg	$388	7-10 days	7-10 days
100 µg	$618	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Bioactivity

Bioactivity	Human IL-18BP, hFc Tag captured on CM5 Chip via Protein A can bind Human IL-37, No Tag with an affinity constant of 0.12 μM as determined in SPR assay (Biacore T200).
Description	IL-37 Protein, Human, Recombinant V2 is expressed in E. coli. The accession number is Q9NZH6-2.
Species	Human
Expression System	E. coli
Tag	Tag Free
Accession Number	Q9NZH6-2
Construction	Lys27-Asp192
Protein Purity	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from 0.22 μm filtered solution in 20 mM PBS, 2 mM DTT (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Reconstitute the lyophilized protein in sterile deionized water. The product concentration should not be less than 100 μg/mL. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	interleukin 37, IL-37, IL37, IL-1RP1, IL1RP1, IL-1H4, IL1H4, IL-1H, IL-1F7, IL1F7, FIL1Z, FIL1(ζ), FIL1(ZETA), FIL1
Research Background	IL-37 is a unique member of the IL-1 family of cytokines, which functions as a natural suppressor of inflammatory and immune responses. Immune and non-immune cells produce IL-37 precursor following pro-inflammatory stimuli. Following activating cleavage by caspase-1, mature IL-37 translocates to the nucleus, where it suppresses transcription of pro-inflammatory genes.

Chemical Properties

Molecular Weight

18.55 kDa (Predicted and reducing conditions)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.