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Menbutone

Name: Menbutone
Brand: TargetMol
SKU: T1148
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1148Cas No. 3562-99-0

Alias Naftobil, Genabilin, Genabilic acid

Menbutone (Genabilin) is a derivative of oxobutyric acid, and is a choleretic. Menbutone shows a rapid onset of action, reaching its maximum plasma level within 1 hour and lasting for roughly 10 hours.

Menbutone

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Purity: 97.48%

Catalog No. T1148Alias Naftobil, Genabilin, Genabilic acidCas No. 3562-99-0

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$30	In Stock	In Stock
500 mg	$60	-	In Stock
1 g	$79	-	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.48%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Menbutone AI Summary

Menbutone shows bioactivity related to the S16 Schwann cell PMP22 intronic element firefly luciferase assay with a potency of 642.4 nM. Additionally, it exhibits antiviral activity against SARS-CoV-2, providing a mixed inhibition profile. In Caco-2 cells, it inhibits virus-induced cytotoxicity by 1.94% at 10 µM after 48 hours. In HRCE cells, the compound showed a low level of activity with a hit score of 0.04313 against the USA-WA1/2020 strain at MOI 0.4 over 96 hours. In VERO-6 cells, at the same concentration and time period, it achieved an inhibition percentage of 0.04%. Menbutone also inhibits the SARS-CoV-2 3CL-Pro protease by 11.97% at 20 µM based on a FRET response from a peptide substrate. Furthermore, it shows inhibition of human HDAC6 activity, with an inhibition of 0.61% in an enzymatic assay using a commercial peptide substrate, while showing -8.25% inhibition with a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Menbutone (Genabilin) is a derivative of oxobutyric acid, and is a choleretic. Menbutone shows a rapid onset of action, reaching its maximum plasma level within 1 hour and lasting for roughly 10 hours.
Synonyms	Naftobil, Genabilin, Genabilic acid

Chemical Properties

Molecular Weight	258.27
Formula	C₁₅H₁₄O₄
Cas No.	3562-99-0
Smiles	C(CCC(O)=O)(=O)C=1C2=C(C(OC)=CC1)C=CC=C2
Relative Density.	1.249 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (193.6 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.74 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8719 mL	19.3596 mL	38.7192 mL	193.5958 mL
5 mM	0.7744 mL	3.8719 mL	7.7438 mL	38.7192 mL
10 mM	0.3872 mL	1.9360 mL	3.8719 mL	19.3596 mL
20 mM	0.1936 mL	0.9680 mL	1.9360 mL	9.6798 mL
50 mM	0.0774 mL	0.3872 mL	0.7744 mL	3.8719 mL
100 mM	0.0387 mL	0.1936 mL	0.3872 mL	1.9360 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc