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ZnPc-O3-JQ1

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Catalog No. T211273

ZnPc-O3-JQ1 is a light-activated BRD4 degrader. Under light exposure, ZnPc-O3-JQ1 generates reactive oxygen species (ROS), leading to the degradation of BRD4. This degradation results in the downregulation of HIF-1α, effectively countering the tumor hypoxia-induced resistance to photodynamic therapy (PDT). ZnPc-O3-JQ1 exhibits both Type I and Type II PDT mechanisms. The structure of ZnPc-O3-JQ1 includes three components: a BRD4 ligand, a linker, and a photosensitizer.

ZnPc-O3-JQ1

ZnPc-O3-JQ1

😃Good
Catalog No. T211273
ZnPc-O3-JQ1 is a light-activated BRD4 degrader. Under light exposure, ZnPc-O3-JQ1 generates reactive oxygen species (ROS), leading to the degradation of BRD4. This degradation results in the downregulation of HIF-1α, effectively countering the tumor hypoxia-induced resistance to photodynamic therapy (PDT). ZnPc-O3-JQ1 exhibits both Type I and Type II PDT mechanisms. The structure of ZnPc-O3-JQ1 includes three components: a BRD4 ligand, a linker, and a photosensitizer.
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Product Introduction

Bioactivity
Description
ZnPc-O3-JQ1 is a light-activated BRD4 degrader. Under light exposure, ZnPc-O3-JQ1 generates reactive oxygen species (ROS), leading to the degradation of BRD4. This degradation results in the downregulation of HIF-1α, effectively countering the tumor hypoxia-induced resistance to photodynamic therapy (PDT). ZnPc-O3-JQ1 exhibits both Type I and Type II PDT mechanisms. The structure of ZnPc-O3-JQ1 includes three components: a BRD4 ligand, a linker, and a photosensitizer.
Chemical Properties
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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