Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RAGE/SERT-IN-1 is a potent, orally active inhibitor of advanced glycation end products (RAGE) and serotonin transporter (SERT), with IC50 values of 8.26 μM and 31.09 nM, respectively. It demonstrates a significant neuroprotective effect against Aβ25-35-induced neuronal damage and alleviates depressive behavior in mice. RAGE/SERT-IN-1 is useful for research on the comorbidity of Alzheimer's disease and depression [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 8-10 weeks | $ 1,670.00 | |
50 mg | 8-10 weeks | $ 2,180.00 | |
100 mg | 8-10 weeks | $ 2,800.00 |
Description | RAGE/SERT-IN-1 is a potent, orally active inhibitor of advanced glycation end products (RAGE) and serotonin transporter (SERT), with IC50 values of 8.26 μM and 31.09 nM, respectively. It demonstrates a significant neuroprotective effect against Aβ25-35-induced neuronal damage and alleviates depressive behavior in mice. RAGE/SERT-IN-1 is useful for research on the comorbidity of Alzheimer's disease and depression [1]. |
In vitro | RAGE/SERT-IN-1 (compound 12) at concentrations ranging from 1-20 μM, when applied for 24 hours, does not substantially impact the viability of SH-SY5Y cells [1]. |
In vivo | RAGE/SERT-IN-1 (0-10 μM; 60 min) exhibits robust liver microsomal stability and negligible inhibition of primary CYP enzymes [1]. The compound, when administered intraperitoneally (IP) at single doses of 100 and 200 mg/kg, does not result in mortality or significant alterations in organ-to-body weight ratios at the lower dose of 100 mg/kg in mice [1]. A single oral dose (PO) of RAGE/SERT-IN-1 at 60 mg/kg markedly decreases immobility time in the tail suspension test, suggesting antidepressant-like activity [1]. Furthermore, RAGE/SERT-IN-1 administered orally (60 mg/kg) and intravenously (IV) (10 mg/kg) demonstrates favorable pharmacokinetic profiles in mice, with parameters for PO and IV routes, respectively, indicating a half-life (T 1/2) of 5.55 and 3.46 hours, maximum concentration (C max) of 4935 and 51745 ng/mL, area under the curve (AUC 0-∞) of 24684 and 23653 ng/mL·h, clearance (CL) of 7.09 mL/min/kg, steady-state volume of distribution (V SS) of 1037 L/kg, and bioavailability (F) of 17.1% [1]. |
Molecular Weight | 637.28 |
Formula | C38H41ClN4OS |
CAS No. | 2766739-35-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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RAGE/SERT-IN-1 2766739-35-7 inhibitor inhibit