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Edaglitazone
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Catalog No. T27239Cas No. 213411-83-7
Alias R-483, Edaglitazone sodium, BM-13.1258
Edaglitazone (R-483) is an orally active, selective and potent PPARγ agonist showing affinity for both PPARα and PPARγ. Edaglitazone displays antiplatelet activity and can be used in studies of diabetes mellitus and obesity.
Edaglitazone
Copy Product Info😃Good
Catalog No. T27239Alias R-483, Edaglitazone sodium, BM-13.1258Cas No. 213411-83-7
Edaglitazone (R-483) is an orally active, selective and potent PPARγ agonist showing affinity for both PPARα and PPARγ. Edaglitazone displays antiplatelet activity and can be used in studies of diabetes mellitus and obesity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $519 | 35 days | 35 days |
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| Description | Edaglitazone (R-483) is an orally active, selective and potent PPARγ agonist showing affinity for both PPARα and PPARγ. Edaglitazone displays antiplatelet activity and can be used in studies of diabetes mellitus and obesity. |
| Targets&IC50 | PPARα:1053 nM (EC50), PPARγ:35.6 nM (EC50) |
| In vitro | METHODS: To elucidate the mechanism of the antiplatelet effect of edaglitazone, platelet cAMP levels were assessed using edaglitazone (3, 6, and 12 μM), Consistent with the aggregation assay, RESULTS: Edaglitazone increased platelet cAMP levels in a concentration-dependent manner, suggesting that its antiplatelet effect is partly mediated by the regulation of cAMP levels. [1] |
| Synonyms | R-483, Edaglitazone sodium, BM-13.1258 |
| Molecular Weight | 464.56 |
| Formula | C24H20N2O4S2 |
| Cas No. | 213411-83-7 |
| Smiles | O=C1SC(C(=O)N1)CC2=CC=C(OCCC=3N=C(OC3C)C=4C=CC=CC4)C=5C=CSC52 |
| Relative Density. | 1.374 g/cm3 |
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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