Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SSM3 tetraTFA hydrate is a potent synthetic inhibitor of furin, exhibiting an EC50 of 54 nM and a Ki of 12 nM. It effectively inhibits the furin-dependent cell surface processing of anthrax protective antigen-83 in vitro [1] [2].
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Description | SSM3 tetraTFA hydrate is a potent synthetic inhibitor of furin, exhibiting an EC50 of 54 nM and a Ki of 12 nM. It effectively inhibits the furin-dependent cell surface processing of anthrax protective antigen-83 in vitro [1] [2]. |
In vitro | SSM3 tetraTFA hydrate effectively inhibits furin-mediated cleavage, exhibiting an EC50 value of 54 nM for the Pyr-RTKR-AMC substrate in both in vitro assays and cell-based tests [2]. It also dose-dependently prevents the furin-dependent conversion of PA83 to PA63 in cleavage reactions, with concentrations ranging from 0.1-25 μM [2]. The compound demonstrates comparable inhibitory potency against furin (Ki = 0.012 μM) and PC6B (Ki = 0.004 μM), with a preference for furin over PACE4 by 2- to 10-fold (Ki = 0.041 μM) and over PC7 by 11- to 76-fold (Ki = 0.595 μM). While SSM3 tetraTFA hydrate is less effective against LF (Ki = 1.241 μM) by 25- to 167-fold compared to furin, it does not significantly inhibit trypsin and MT1-MMP [2]. |
Molecular Weight | 979.7 |
Formula | C30H36F12N12O10.1.5H2O |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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SSM3 tetraTFA hydrate Others inhibitor inhibit