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Anti-Phospho-PTEN (Ser380) Antibody (6H501)
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Catalog No. TMAH-00949
Alias TEP1, PTEN1, Phospho-PTEN (S380), Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Phosphatase and tensin like protein, Phosphatase and tensin homolog, Mutated in multiple advanced cancers 1, MMAC1 phosphatase and tensin homolog deleted on chromosome 10, MMAC1, MHAM, MGC11227, GLM2, DEC, BZS, 10q23del
Anti-Phospho-PTEN (Ser380) Antibody (6H501) is an antibody targeting Phospho-PTEN (Ser380). Anti-Phospho-PTEN (Ser380) Antibody (6H501) can be used in ELISA, WB.
Anti-Phospho-PTEN (Ser380) Antibody (6H501)
Anti-Phospho-PTEN (Ser380) Antibody (6H501)
😃Good
Catalog No. TMAH-00949Alias TEP1, PTEN1, Phospho-PTEN (S380), Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Phosphatase and tensin like protein, Phosphatase and tensin homolog, Mutated in multiple advanced cancers 1, MMAC1 phosphatase and tensin homolog deleted on chromosome 10, MMAC1, MHAM, MGC11227, GLM2, DEC, BZS, 10q23del
Anti-Phospho-PTEN (Ser380) Antibody (6H501) is an antibody targeting Phospho-PTEN (Ser380). Anti-Phospho-PTEN (Ser380) Antibody (6H501) can be used in ELISA, WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $209 | 7-10 days | |
| 100 μL | $347 | 7-10 days |
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Chemical Properties
| Description | Anti-Phospho-PTEN (Ser380) Antibody (6H501) is an antibody targeting Phospho-PTEN (Ser380). Anti-Phospho-PTEN (Ser380) Antibody (6H501) can be used in ELISA, WB. |
| Alias | TEP1, PTEN1, Phospho-PTEN (S380), Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Phosphatase and tensin like protein, Phosphatase and tensin homolog, Mutated in multiple advanced cancers 1, MMAC1 phosphatase and tensin homolog deleted on chromosome 10, MMAC1, MHAM, MGC11227, GLM2, DEC, BZS, 10q23del |
| Ig Type | Rabbit IgG |
| Clone | 6H501 |
| Reactivity | Human |
| Verified Activity | Western Blot -Positive WB detected in HepG2 whole cell lysate -All lanes Phospho-PTEN antibody at 1.9μg/ml -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 54 KDa -Observed band size: 54 KDa |
| Application | ELISA, WB |
| Recommended Dose | WB:1:500-1:5000. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cytoplasm. Nucleus. Nucleus, PML body.; [Isoform alpha]: Secreted. Note=May be secreted via a classical signal peptide and reenter into cells with the help of a poly-Arg motif. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with MAGI2 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability. In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement. Functional kinase, like isoform 1 it antagonizes the PI3K-AKT/PKB signaling pathway. Plays a role in mitochondrial energetic metabolism by promoting COX activity and ATP production, via collaboration with isoform 1 in increasing protein levels of PINK1. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human Phospho-PTEN (S380) |
| Antigen Species | Human |
| Gene ID | 5728 |
| Uniprot ID | |
| Biology Area | Cell Biology |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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