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Capecitabine-2',3'-cyclic Carbonate

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Catalog No. T64318Cas No. 921769-65-5

Capecitabine-2',3'-cyclic Carbonate is a antiproliferative agent.

Capecitabine-2',3'-cyclic Carbonate

Capecitabine-2',3'-cyclic Carbonate

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Purity: 99.72%
Catalog No. T64318Cas No. 921769-65-5
Capecitabine-2',3'-cyclic Carbonate is a antiproliferative agent.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$40-In Stock
50 mg$56-In Stock
1 mL x 10 mM (in DMSO)$39-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.72%
Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
Capecitabine-2',3'-cyclic Carbonate is a antiproliferative agent.
In vitro
Capecitabine-2',3'-cyclic Carbonate inhibits the proliferation of tumor cells with IC50 of 0.08mg/mL, 0.08mg/mL, 0.14mg/mL and 0.18mg/mL for HeLa, MCF-7, PZ-HPV-7 and NCI-69, respectively[1].
Chemical Properties
Molecular Weight385.34
FormulaC16H20FN3O7
Cas No.921769-65-5
SmilesO=C1N([C@H]2[C@]3([C@@]([C@@H](C)O2)(OC(=O)O3)[H])[H])C=C(F)C(NC(OCCCCC)=O)=N1
Relative Density.1.58 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 27.5 mg/mL (71.37 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5951 mL12.9756 mL25.9511 mL129.7555 mL
5 mM0.5190 mL2.5951 mL5.1902 mL25.9511 mL
10 mM0.2595 mL1.2976 mL2.5951 mL12.9756 mL
20 mM0.1298 mL0.6488 mL1.2976 mL6.4878 mL
50 mM0.0519 mL0.2595 mL0.5190 mL2.5951 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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