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BRD4884

Name: BRD4884
Brand: TargetMol
SKU: T23821
Price: 54 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: BRD-4884) Copy Product Info

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Synonyms: BRD-4884

Catalog No. T23821 Copy Product Info

Purity: 99.21%

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BRD4884 is a highly selective and efficient HDAC1 and HDAC2 inhibitor that also inhibits HDAC3, used in research on neurological disorders.

Cas No. 1404559-91-6

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Pack Size	Price	USA Stock	Global Stock
500 µg	$54	In Stock	In Stock
1 mg	$79	In Stock	In Stock
5 mg	$189	In Stock	In Stock
10 mg	$283	In Stock	In Stock
25 mg	$479	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.21%

Appearance:Solid

Color:White to Gray

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	BRD4884 is a highly selective and efficient HDAC1 and HDAC2 inhibitor that also inhibits HDAC3, used in research on neurological disorders.
Targets & IC50	HDAC3:1.09 μM, HDAC2:62 nM, HDAC1:29 nM
In vitro	BRD4884 is a potent HDAC inhibitor with IC50 values of 29 nM, 62 nM, and 1.09 µM for HDAC1, 2, and 3, respectively. BRD4884 (10 μM for 24 hours) increased acetylation of histone H4K12 and H3K9 in mouse forebrain primary neuron cultures. [1]
In vivo	BRD4884 has a half-life of 0.9 hours in mice and has good brain permeability. BRD4884 (10 and 1 mg/kg, intraperitoneal injection) salvaged memory deficits associated with P25-induced neurodegeneration in situational fear conditioning. [1]
Synonyms	BRD-4884

Chemical Properties

Molecular Weight	314.35
Formula	C₁₈H₁₉FN₂O₂
Cas No.	1404559-91-6
Smiles	O=C(NC1=CC(=CC=C1N)C=2C=CC(F)=CC2)C3CCOCC3
Relative Density.	1.268 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (63.62 mM), Sonication and heating are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1812 mL	15.9058 mL	31.8117 mL	159.0584 mL
5 mM	0.6362 mL	3.1812 mL	6.3623 mL	31.8117 mL
10 mM	0.3181 mL	1.5906 mL	3.1812 mL	15.9058 mL
20 mM	0.1591 mL	0.7953 mL	1.5906 mL	7.9529 mL
50 mM	0.0636 mL	0.3181 mL	0.6362 mL	3.1812 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc