FGF-19 Protein, Human, Recombinant (Active)

Name: FGF-19 Protein, Human, Recombinant (Active)
Brand: TargetMol
SKU: TMPX-00008
Rating: 4.5 (1 reviews)

(Synonyms: Fibroblast growth factor 19, FGF-19, FGF19) Copy Product Info

Synonyms: Fibroblast growth factor 19, FGF-19, FGF19

Catalog No. TMPX-00008 Copy Product Info

FGF-19 Protein, Human, Recombinant (Active) is expressed in E. coli. The accession number is O95750.

Customer service consultation

Pack Size	Price	USA Stock	Global Stock
5 µg	$86	7-10 days	7-10 days
10 µg	$145	7-10 days	7-10 days
20 µg	$246	7-10 days	7-10 days
50 µg	$422	7-10 days	7-10 days
100 µg	$718	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Resource Download

User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Fully biologically active when compared to standard. The biological activity is measured by its binding ability in a functional ELISA. Immobilized rHuFGF R4 at 5 µg/ml can bind rHuFGF-19 with a linear range of 3-200 ng/ml. Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 150 ng/ml, corresponding to a specific activity of > 6.7 × 10^3 IU/mg.
Description	FGF-19 Protein, Human, Recombinant (Active) is expressed in E. coli. The accession number is O95750.
Species	Human
Expression System	E. coli
Tag	Tag Free
Accession Number	O95750
Amino Acid	MRPLAFSDAG PHVHYGWGDP IRLRHLYTSG PHGLSSCFLR IRADGVVDCA RGQSAHSLLE IKAVALRTVA IKGVHSVRYL CMGADGKMQG LLQYSEEDCA FEEEIRPDGY NVYRSEKHRL PVSLSSAKQR QLYKNRGFLP LSHFLPMLPM VPEEPEDLRG HLESDMFSSP LETDSMDPFG LVTGLEAVRS PSFEK
Construction	Arg23-Lys216
Protein Purity	> 95% as determined by SDS-PAGE; > 95% as determined by HPLC
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a 0.2 µm filtered concentrated solution in PBS, pH 7.4.
Reconstitution	Reconstitute the lyophilized protein in sterile deionized water or aqueous buffer containing 0.1 % BSA. The product concentration should not be less than 100 μg/mL. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	Fibroblast growth factor 19, FGF-19, FGF19
Research Background	Human FGF-19 is encoded by the FGF19 gene. FGF-19 belongs to the FGF-19 subfamily which has three members FGF-19, 21, 23. FGFs are classically considered to be paracrine factors and are known for their roles in tissue patterning and organogenesis during embryogenesis. By contrast, the FGF-19 subfamily has recently been shown to function in an endocrine manner. Members of this subfamily have poor ability of binding to heparin binding site which is a crucial factor in ligand-receptor complex formation. β-Klotho has been identified as co-factor required for FGF-19, 21, 23 signaling. It can obviously increase ligand-receptor affinity. Unlike most FGFs which bind to and activate more than one FGF receptor, FGF19 is a specific ligand for FGF R4. In FGF-19 transgenic mice, reducing liver triglycerides, increasing fatty acid oxidation, reducing glucose levels and improving insulin sensitivity can be observed.

Chemical Properties

Molecular Weight

21.8 kDa (Predicted)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.