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(S)-Carvedilol
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Catalog No. T12794Cas No. 95094-00-1
Alias (S)-BM 14190
(S)-Carvedilol is a non-selective β/α-1 blocker.It exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX).
(S)-Carvedilol
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Catalog No. T12794Alias (S)-BM 14190Cas No. 95094-00-1
(S)-Carvedilol is a non-selective β/α-1 blocker.It exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $1,350 | 3-6 months | 3-6 months | |
| 50 mg | $1,760 | 3-6 months | 3-6 months | |
| 100 mg | $2,500 | 3-6 months | 3-6 months |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | (S)-Carvedilol is a non-selective β/α-1 blocker.It exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX). |
| In vitro | (S)-Carvedilol exhibits beta-receptor blocking activity that is approximately 100 times more potent than that of its enantiomer (R)-Carvedilol, though both enantiomers demonstrate equal efficacy as alpha-blockers. Treatment with (S)-Carvedilol markedly enhances the expression of p-eNOS in HUVECs. Additionally, (S)-Carvedilol effectively reduces Doxorubicin (DOX)-induced cell death, apoptotic alterations, and depletion of mitochondrial membrane potential. It also mitigates oxidative stress by increasing superoxide dismutase and catalase activity, while reducing malondialdehyde levels and reactive oxygen species, mediated through the PI3K/AKT/eNOS pathway in vitro. |
| Synonyms | (S)-BM 14190 |
| Molecular Weight | 406.47 |
| Formula | C24H26N2O4 |
| Cas No. | 95094-00-1 |
| Smiles | COc1ccccc1OCCNC[C@H](O)COc1cccc2[nH]c3ccccc3c12 |
| Relative Density. | 1.25 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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