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DSP Crosslinker

Name: DSP Crosslinker
Brand: TargetMol
SKU: T15175
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T15175Cas No. 57757-57-0

DSP Crosslinker, used in antibody-drug conjugates (ADCs) synthesis, is a cleavable ADC linker[1].

DSP Crosslinker

🥰Excellent

Purity: 99.94%

Catalog No. T15175Cas No. 57757-57-0

DSP Crosslinker, used in antibody-drug conjugates (ADCs) synthesis, is a cleavable ADC linker[1].

Pack Size	Price	Availability
25 mg	$30	In Stock
50 mg	$39	In Stock
100 mg	$55	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock

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Batch Information

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Purity:99.94%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	DSP Crosslinker, used in antibody-drug conjugates (ADCs) synthesis, is a cleavable ADC linker[1].
In vitro	ADCs consist of an antibody attached to an ADC cytotoxin through an ADC linker.

Chemical Properties

Molecular Weight	404.42
Formula	C₁₄H₁₆N₂O₈S₂
Cas No.	57757-57-0
Smiles	O(C(CCSSCCC(ON1C(=O)CCC1=O)=O)=O)N2C(=O)CCC2=O
Relative Density.	1.57 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (222.54 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4727 mL	12.3634 mL	24.7268 mL	123.6338 mL
5 mM	0.4945 mL	2.4727 mL	4.9454 mL	24.7268 mL
10 mM	0.2473 mL	1.2363 mL	2.4727 mL	12.3634 mL
20 mM	0.1236 mL	0.6182 mL	1.2363 mL	6.1817 mL
50 mM	0.0495 mL	0.2473 mL	0.4945 mL	2.4727 mL
100 mM	0.0247 mL	0.1236 mL	0.2473 mL	1.2363 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc